Completed

Efficacy of Microneedling With Topical Vitamin C in Treatment of Acne Scarring

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What is being tested

Dermaroller

+ Topical Vitamin C

DeviceDrug
Who is being recruted

Acne Vulgaris+2

+ Sebaceous Gland Diseases

+ Skin Diseases

Over 18 Years
+9 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Phase 1 & 2
Interventional
Study Start: June 2016
See protocol details

Summary

Principal SponsorSohag University
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: June 1, 2016

Actual date on which the first participant was enrolled.

Study population: Each study group included 10 patients. Detailed history and full clinical examination was conducted for each patient. Patients had 6 visits at one month interval to receive treatment and evaluated one month after the end of treatment visits. The first group: Patients received a series of six treatments by dermaroller at 4 weeks interval and no topical anti scar treatment in between sessions. The second group: Received a series of six treatments by dermaroller at 4 weeks interval with the same maneuver and instructions as first group and each session was followed by immediate application of topical vit.C serum plus once daily application in between sessions. The third group: received once daily topical vit.C serum capsule at night for six months. With monthly evaluation. Assessment of patients during visits was as follow: A) Clinical evaluation by B) Photographic documentation C) Patient satisfaction D) Safety assessment

Official TitleEfficacy of Microneedling With Topical Vitamin C in Treatment of Acne Scarring
NCT03522922
Principal SponsorSohag University
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

30 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Acne VulgarisSebaceous Gland DiseasesSkin DiseasesSkin and Connective Tissue DiseasesAcneiform Eruptions

Criteria

1 inclusion criteria required to participate
Facial acne scars
8 exclusion criteria prevent from participating
Active inflammatory acne.
Active infection in the treatment area (e.g., herpes simplex and verrucae).
Melanoma or lesions suspected of malignancy.
Isotretinoin use in the past year.
Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

3 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Active Comparator
Patients received a series of six treatments by dermaroller at 4 weeks interval with the same maneuver and instructions as first group and each session was followed by immediate application of topical vitamin C serum plus once daily application in between sessions.

Group II

Active Comparator
Patients received a series of six treatments by dermaroller at 4 weeks interval and no topical anti scar treatment in between sessions.

Group III

Active Comparator
Patients received once daily topical vitamin C serum capsule at night for six months. With monthly evaluation.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Sohag Faculty of Medicine

Sohag, EgyptOpen Sohag Faculty of Medicine in Google Maps
CompletedOne Study Center