Completed

Aerobic Exercise Impact on Metabolic Responses and Abdominal Obesity in Women with Metabolic Syndrome

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Study Aim

This study aims to evaluate the impact of aerobic exercise on metabolic responses and abdominal obesity in women with metabolic syndrome, by measuring changes in abdominal fat, epinephrine, free fatty acids, glycerol, noradrenaline, oxyntomodulin, and weight over a 12-week period and a 4-week detraining period.

What is being tested

Supervised treadmill group (%70 VO2 max) (group 1)

+ Supervised treadmill group (%50 VO2 max) (group 2)

+ ECE PEDO pedometer group (%50 VO2 max) (group 3)

OtherDevice
Who is being recruted

Hyperinsulinism+3

+ Insulin Resistance

+ Metabolic Diseases

From 25 to 65 Years
+3 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: August 2016
See protocol details

Summary

Principal SponsorPamukkale University
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: August 1, 2016

Actual date on which the first participant was enrolled.

This study focuses on understanding the effects of aerobic exercise, performed at different intensities and durations, on metabolic and hormonal responses, as well as abdominal obesity in women diagnosed with metabolic syndrome. The research aims to provide insights into how varying exercise routines can impact these women's health. By exploring these effects, the study hopes to contribute to the development of more effective exercise strategies that can help manage metabolic syndrome and reduce abdominal obesity. Participants in this study are divided into three groups. The first group engages in high-intensity treadmill exercises, the second group in low-intensity treadmill exercises, and the third group in low-intensity walking with a pedometer. The progress of each participant is tracked over a 12-week period, followed by a 4-week detraining period. Various measurements, such as weight, BMI, waist circumference, blood sugar levels, and fat distribution, are taken at the beginning, end, and after the detraining period. Blood samples are also collected to evaluate changes in hormonal and metabolic parameters. The study's primary outcomes include changes in abdominal fat, hormone levels, and weight, which are expected to provide valuable insights into the benefits of different exercise intensities and durations.

Official TitleEffects of Different Intensities and Durations of Aerobic Exercise Training and Detraining on Metabolic, Hormonal Responses and Abdominal Obesity in Women With Metabolic Syndrome.
NCT03445741
Principal SponsorPamukkale University
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

60 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Female

Biological sex of participants that are eligible to enroll.

From 25 to 65 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

HyperinsulinismInsulin ResistanceMetabolic DiseasesNutritional and Metabolic DiseasesMetabolic SyndromeGlucose Metabolism Disorders

Criteria

2 inclusion criteria required to participate
eligible participants who meet the criteria for inclusion were women with metabolic syndrome diagnosis according to National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria and were 25-65 years old.

Participants were well communicative, motivated and willing to participate in the study.

1 exclusion criteria prevent from participating
The exclusion criteria were presence of uncontrolled hypertension, type 2 diabetes mellitus, atherosclerotic heart disease, using drugs to affect thyroid, lipids metabolism and insulin sensitization, musculoskeletal or systemic diseases contradicting the exercise, a neurological or psychiatric disease affecting cooperation and cognitive function.

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

3 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Active Comparator
Supervised treadmill group (%70 VO2 max) (group 1): The participants were instructed walking exercise at their target heart rate, (% 70 of maximum oxygen consumption) on a treadmill in Sports Rehabilitation Unit of Pamukkale University.

Group II

Experimental
Supervised treadmill group (%50 VO2 max) (group 2): The participants were instructed walking exercise at their target heart rate, (% 50 of maximum oxygen consumption) on a treadmill in Sports Rehabilitation Unit of Pamukkale University.

Group III

Experimental
ECE PEDO pedometer group (%50 VO2 max) (group 3): The participants were instructed walking with ECE PEDO which the number of steps taken in a minute corresponding to target HR at % 50 of maximum oxygen consumption were provided.

Study Objectives

Primary Objectives

Study Centers

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CompletedNo study centers