Effect of Various Sealers on Healing of Teeth With Apical Periodontitis: A Clinical Study
Zinc oxide based sealer
+ Epoxy resin based sealer
+ Bioactive silicone based sealer
Jaw Diseases+4
+ Stomatognathic Diseases
+ Mouth Diseases
Treatment Study
Summary
Study start date: November 1, 2016
Actual date on which the first participant was enrolled.Various sealers with different chemical composition and properties are available but it is yet not clear if one sealer is superior to other in terms of healing of apical periodontitis. Three different groups of sealers will be used- a zinc oxide based sealer, an epoxy resin based sealer and a bioactive silicone based sealer. Mature mandibular permanent molar with the diagnosis of apical periodontitis (as confirmed clinically \& by periapical radiograph) will be chosen for the study. Primary non surgical root canal treatment will be performed. The sealer will be randomly selected just before obturation of root canals. The patient will be allotted to one of the three groups. * Group I: Zinc oxide eugenol sealer group. The material will be mixed according to manufacturer instructions and applied to canals using a lentulospiral and the obturation will be performed. * Group II: Epoxy resin based sealer group. The material will be mixed according to the manufacturer's instructions and obturation will be done. * Group III: Bioactive silicone based sealer: The material will be used according to the manufacturer's instruction and obturation will be performed
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.99 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Treatment Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.From 18 to 60 Years
Range of ages for which participants are eligible to join.Healthy volunteers allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Inclusion Criteria: The inclusion criteria of the study will include: * Patient willing to participate in the study. * Age \>18 years. * No history of antibiotic use within the past month or requiring antibiotic premedication * No history of prior analgesic use during past 24 hrs. * Mature permanent mandibular molar having apical periodontitis requiring primary root canal treatment. * There must be a radiographic evidence of periapical radiolucency (minimum size 2mmx2mm) and a diagnosis of pulpal necrosis, as confirmed by negative response to cold and electrical tests; and absence of bleeding on entering the pulp chamber Exclusion Criteria: * Re-treatment * Unwillingness of patients * The presence of a difficult canal anatomy (root canals with an extreme curvature ≥30 deg), internal or external resorption and immature teeth. * Accident or complication during treatment (calcified canals ,inability to achieve apical patency in any canals) Immuno-compromised, diabetic, pregnant and hypertensive patients. * Teeth that are peridontally compromised
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.3 intervention groups are designated in this study
This study does not include a placebo group
Treatment Groups
Group I
Active ComparatorGroup II
ExperimentalGroup III
ExperimentalStudy Objectives
Primary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location
Post Graduate Institute of Dental Sciences
Rohtak, IndiaOpen Post Graduate Institute of Dental Sciences in Google Maps