Does Colectomy Predispose to Small Intestinal Bacterial (SIBO) and Fungal Overgrowth (SIFO)
Data Collection
Collected from past medical records and data - RetrospectiveOther
Utilizing specific methods not covered by standard models in order to address unique research questions.Summary
Study start date: February 24, 2015
Actual date on which the first participant was enrolled.After subtotal colectomy, 40% of patients report abdominal pain, gas and diarrhea, and poor quality of life; whose etiology is unknown. The investigators determined whether small intestinal bacterial (SIBO or fungal overgrowth SIFO) could cause these sympotoms (> 1 year).
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.100 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Other
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.Over 18 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Criteria
Inclusion Criteria: patients who were referred to a specialist motility center over 4 year period with: * Unexplained gastrointestinal symptoms such as gas, bloating, belching, diarrhea, and abdominal discomfort * history of colectomy * patients with no history of colectomy * patients included who had normal: upper endoscopy, colonoscopy, computerized abdominal tomography scan, and normal hematology, biochemical profiles, tissue transglutaminase antibody, thyroid stimulating hormone, and normal right upper quadrant ultrasound scan. * patients with glucose breath test and/or duodenal aspirate Exclusion Criteria: * patients with upper gut or small bowel surgery * Patients who were hospitalized or with serious cardiac or pulmonary or neurologic comorbidities * Patients with intestinal strictures or known intestinal motility disorders such as scleroderma or pseudo-obstruction syndrome
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.Study Objectives
Primary Objectives
Secondary Objectives