Completed

Comparison of the Effects of Two Tear Substitutes in Patients With Dry Eye Syndrome

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What is being tested

Liposic

+ Tears Naturale Forte

Drug
Who is being recruted

Eye Diseases

+ Lacrimal Apparatus Diseases

+ Dry Eye Syndromes

From 20 to 40 Years
+7 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: July 2017
See protocol details

Summary

Principal SponsorHuaxia Eye Hospital Group
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: July 1, 2017

Actual date on which the first participant was enrolled.

With the potential to address evaporative dry eye, Liposic and Tears Naturale Forte have been developed in which phospholipid liposomes are delivered to the tear film via the surface of the closed eyelid. This study compare the effects of Liposic and Tears Naturale Forte application on the lipid and stability of the tear film in dry eye patients

Official TitleComparison of the Effects of Two Tear Substitutes in Patients With Dry Eye Syndrome
NCT03211351
Principal SponsorHuaxia Eye Hospital Group
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

95 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 20 to 40 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Eye DiseasesLacrimal Apparatus DiseasesDry Eye Syndromes

Criteria

5 inclusion criteria required to participate
Age range from 20 year to 40 years
The value of OSDI is over 12
NBUT is less 5 seconds
Schirmer 1 test is less 10mm
Show More Criteria
2 exclusion criteria prevent from participating
Any corneal,conjunctival, or eyelid abnormalities; conjunctivitis; current ocular infection; photophobia that may cause reflex tearing or difficulty in evaluating the patien 's lipid layer;
Known allergic sensitivity to any of the ingredients in Liposic or Tears Naturale Forte

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
Liposic was applied to one eye of patients in this group

Group II

Experimental
Tears Naturale Forte was applied to one eye of patients in this group

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Huaxia Eye Hosptial of Foshan

Foshan, ChinaOpen Huaxia Eye Hosptial of Foshan in Google Maps
CompletedOne Study Center