SleSOBPrefrailty and Sarcopenic Obesity: Insights through Sleep Disturbances and Biomarkers

This study focuses on understanding the link between sleep disturbances and a condition called sarcopenic obesity, which is a combination of muscle loss and obesity, in young-elderly obese individuals. The study aims to detect prefrailty, an early stage of frailty, which can lead to health issues, loss of independence, and poor quality of life. The goal is to explore how sleep problems might contribute to muscle loss and weakness through changes in glucose metabolism and hormone patterns. The study is particularly interested in obese individuals, as obesity is associated with insulin resistance and increased risk for heart diseases and cognitive decline. Participants in this study will visit the clinic in the morning after fasting. They will undergo various tests, including blood samples for routine and specific biochemistry, measurements of height, weight, and body mass index, and assessments of muscle strength and mass. The study will also evaluate glucose metabolism, sympathetic activation, medical history, cognitive function, sleep patterns, and sense of smell. Participants will wear a device for 24 hours to record heart rate, respiratory rate, oxygen saturation, posture, and physical activity. The main outcome of the study is to determine the prevalence of prefrailty among the participants.