Predicting Neurological Outcome Following Out of Hospital Cardiac Arrest (OHCA) by Quantitative Measurement of Serial Serum Biomarkers of Brain Injury.
Data Collection
Collected from today forward - ProspectiveHypoxia+17
+ Brain Diseases
+ Brain Injuries
Cohort
Tracking disease incidence in order to identify risk factors and understand disease progression over time.Summary
Study start date: May 26, 2017
Actual date on which the first participant was enrolled.This study focuses on individuals who experience a cardiac arrest outside of the hospital, a condition known as Out-of-Hospital Cardiac Arrest (OHCA). While some patients regain a heartbeat after aggressive treatment, many face poor outcomes, including low survival rates and potential neurological damage due to lack of oxygen to the brain. Currently, there's no quick, definitive test to predict the neurological outcome for these patients. This research aims to identify biomarkers, or substances in the blood, that could help predict such outcomes, potentially improving care and addressing current challenges in managing OHCA. The study involves a minimal risk procedure where blood samples are taken at various time points after the heartbeat is restored, specifically at 0-59 minutes, and then at 6, 12, 18, 24, 48, 72 hours, and on days 4, 5, and 6. The researchers will examine if the levels of certain biomarkers in these samples correlate with survival to hospital admission, survival to hospital discharge, and neurological function at discharge and after 6 months. The study also includes patients who come to the emergency department with chest pain but not cardiac arrest, to provide a comparative group.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.32 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Cohort
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.Over 18 Years
Range of ages for which participants are eligible to join.Healthy volunteers allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Inclusion Criteria: \- \>18 years old Study cohort: * Non-traumatic out of hospital cardiac arrest * Control cohort: * Chest pain of non-cardiac etiology Exclusion Criteria: Both cohorts: * Females of child bearing age with positive pregnancy test * Neurodegenerative disease or other neurological disorder (dementia, Parkinson's disease, multiple sclerosis, seizure disorder, or brain tumours) * History of neurosurgery within the last 30 days Acute brain injury within the last 30 days (ischemic/ haemorrhagic stroke, traumatic brain injury) Subject is anemic OR donated blood within the last 8 weeks OR has a hematological disorder that requires transfusions Subject has history of liver failure OR renal failure Study cohort: Advanced directives against resuscitation Traumatic cardiac arrest In hospital cardiac arrest Failure to attain ROSC + visible signs of death (livor mortis, rigor mortis) Control cohort: EKG changes: New ST-elevation consistent with myocardial infarction NSTEMI Hemodynamically unstable
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.Study Objectives
Primary Objectives
Secondary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location