Completed

Comparison of BlephEx to MiBoflo as Treatment Options for Blepharitis

0 criteria met from your profileSee at a glance how your profile meets each eligibility criteria.
What is being tested

Blephex

+ MiboFlo

Device
Who is being recruted

Meibomian Gland Dysfunction+2

+ Eye Diseases

+ Eyelid Diseases

Over 18 Years
+2 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: May 2015
See protocol details

Summary

Principal SponsorUniversity of the Incarnate Word
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: May 1, 2015

Actual date on which the first participant was enrolled.

The investigators have previously studied the effect of the BlephEx instrument (debridement of lid debris) in relieving signs and symptoms of blepharitis (Connor CG et al, ARVO 2014). This previous study demonstrated positive results from the BlephEx treatment. Warming the eyelids (e.g., using warm wash cloths) still remains a viable treatment option for this disease. However, patients are often non-compliant with warm compress therapy due to the requirement of performing it at least twice per day. The MiBoflo delivers uniform and consistent amounts of heat to the eyelid. It is suggested that two treatments over 30 days is adequate to relieve signs and symptoms of Meibomian gland dysfunction. This equipment is currently used in optometric practices in this country. There are no clinical studies comparing BlephEx and MiBoflo as treatment options for blepharitis. Hence, the current study will provide new and useful information on which treatment option may be better for treating blepharitis and Meibomian gland dysfunction. Part of this study will also investigate if a combination of BlephEx and MiBoflo treatments is more beneficial to the patient. The data generated will directly benefit clinical practice and impact several millions of patients who suffer from this Blepharitis and / or Meibomian gland dysfunction.

Official TitleComparison of BlephEx to MiBoflo as Treatment Options for Blepharitis
NCT02952079
Principal SponsorUniversity of the Incarnate Word
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

11 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.


Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Meibomian Gland DysfunctionEye DiseasesEyelid DiseasesLacrimal Apparatus DiseasesDry Eye Syndromes

Criteria

1 inclusion criteria required to participate
Must have dry eye secondary to Meibomian gland dysfunction (posterior blepharitis)

1 exclusion criteria prevent from participating
Must not have active ocular surface infections. Must not be currently using steroids or immunosuppression eye drops.

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Active Comparator
Treatment with the BlephEx instrument (lid margin exfoliation)

Group II

Active Comparator
Treatment with the MiboFlo equipment (heat therapy to eyelids)

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Rosenberg School of Optometry

San Antonio, United StatesOpen Rosenberg School of Optometry in Google Maps
CompletedOne Study Center