Completed

Impact of Aerobic, Resistance, and Combined Exercise on Endothelial Injury in Hypertensive Patients

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What is being tested

AEROBIC

+ RESISTANCE

+ COMBINED

Other
Who is being recruted

Behavior+2

+ Cardiovascular Diseases

+ Hypertension

From 30 to 59 Years
+8 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Supportive Care Study

Interventional
Study Start: January 2016
See protocol details

Summary

Principal SponsorInstituto de Cardiologia do Rio Grande do Sul
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: January 1, 2016

Actual date on which the first participant was enrolled.

This study focuses on understanding how different types of exercise impact the blood vessels in individuals with high blood pressure. High blood pressure can damage blood vessels, leading to heart disease. Regular physical activity is a key part of managing high blood pressure, but the effects of various exercises on blood vessels aren't fully understood. This research aims to fill this gap, potentially improving care for people with high blood pressure by providing insights into the most beneficial forms of exercise. Participants, who are either healthy or have high blood pressure, will engage in one of three exercise routines: aerobic exercise, resistance training, or a combination of both. Exercises will last for 40 minutes. Blood samples will be taken before, during, and after the exercise to measure certain markers of blood vessel health. The study will also monitor blood pressure and measure the widening of a specific arm artery in response to increased blood flow. The results will help understand how different exercises affect blood vessels and could guide exercise recommendations for people with high blood pressure.

Official TitleEffect of Aerobic Exercise, Resistance or Combined in Endothelial Injury in Hypertensive Patients
NCT02937922
Principal SponsorInstituto de Cardiologia do Rio Grande do Sul
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

33 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Supportive Care Study

These studies explore ways to improve comfort and daily life for people living with a condition. They may focus on easing symptoms, reducing treatment side effects, or supporting overall well-being.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 30 to 59 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

BehaviorCardiovascular DiseasesHypertensionMotor ActivityVascular Diseases

Criteria

2 inclusion criteria required to participate
Adults with hypertension;
30 to 59 years old.
6 exclusion criteria prevent from participating
Diabetes;
Heart disease;
Participating in any regular exercise program over the last six months;
Orthopedic impairments or any physical or mental limitation that prevents - achievement of physical exercise;
Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

3 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Active Comparator
The aerobic exercise session (AE) will consist of 40 minutes on an exercise bike in heart rate (HR) corresponding to 60% of heart rate reserve (moderate intensity) acquired by the formula of Karvonen: \[(HR max - HR rest) x desired intensity\] + HR rest; monitored through heart monitor brand Polar and perceived exertion rating (Borg scale of 6-20). It will be added to the exercise time 5-7 minutes to proper heating.

Group II

Active Comparator
The resistance exercise session (RE) will last 40 minutes and will consist in carrying out 4 sets of 12 repetitions with interval of 90 seconds between sets and exercises. The weight will be adjusted to 60% of a maximum repetition (1-RM) in four exercise for the lower limbs: leg press, knee extension, bend knees and plantar flexion (calf). The cadence of each series will be controlled by electronic metronome and performed with 2 seconds in the concentric phase and 2 seconds in the eccentric phase. It will be added to the exercise time 5-7 minutes for the warming to be held in the leg press exercise (one set of 15 to 20 repetitions with 1/3 load set for the session).

Group III

Active Comparator
The combined exercise session (resistance and aerobic) will last 40 minutes. The exercise resistance phase of the combined session will consist of 20 minutes, according to the resistance exercise described above. Immediately after resistance exercise, patients will perform aerobic exercise (AE) for 20 minutes. In order to keep the equivalent time among the three interventions (aerobic exercise resistance and combined) will be performed two series (2 x 12 repetitions) in each resistance exercise.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.
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CompletedNo study centers
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