Probiotics Impact on Bacterial Translocation and Micro-inflammation in Hemodialysis Patients

This study explores the effects of probiotics on hemodialysis patients. It aims to understand how probiotics can modify the bacterial translocation and improve micro-inflammation in these patients. The study is important as it targets a specific population - patients undergoing hemodialysis at the Dialysis Department in the First Affiliated Hospital of Xi'an Jiaotong University. The potential outcomes of this study could lead to improved care and treatment strategies for hemodialysis patients, addressing current challenges in managing their condition. Participants in this study will first go through a 2-week run-in period, after which they will be randomly assigned to receive either probiotics supplements or a placebo for 6 months. All participants will receive face-to-face dietary education from a dietitian and will be encouraged to maintain stable protein and fibre intakes throughout the intervention. The study's results will be measured through a faeces microbial analysis, which will evaluate changes in the gut microbiota. Participants' dietary intakes will be assessed monthly using a semi-quantitative food frequency questionnaire. Adherence to supplements will be monitored by pill count every two weeks. All serious adverse events will be reported to the ethics committee, regardless of whether they are related to the intervention or not.