Completed

myDExTailored myDEx Online HIV Prevention Intervention for Young Men

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What is being tested

myDEx

+ NTHP

Behavioral
Who is being recruted

Blood-Borne Infections+11

+ Urogenital Diseases

+ Genital Diseases

From 18 to 24 Years
+10 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Prevention Study

Interventional
Study Start: November 2016
See protocol details

Summary

Principal SponsorUniversity of Pennsylvania
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: November 1, 2016

Actual date on which the first participant was enrolled.

There's been an increase in new HIV cases among young men who have sex with men (YMSM), aged 18-24. To address this, a tailored, web-based intervention called 'myDEx' is being developed. This program aims to deliver HIV prevention messages based on a single YMSM's relationship expectations and partner-seeking behaviors. To ensure the intervention is appealing and appropriate, a youth advisory board (YAB) provides insight and feedback during its development. The main goal is to align YMSM's relationship experiences and desires with HIV prevention strategies. In this study, participants will engage with either the tailored myDEx intervention or a non-tailored HIV/AIDS prevention (NTHP) comparison intervention. Feedback on the intervention's design and acceptability will be collected from 16 YMSM. After any recommended changes are made, a small pilot randomized controlled trial (RCT) will be launched. This trial will compare myDEx with NTHP to assess intervention feasibility and acceptability, and gather preliminary behavioral data. Assessments will be conducted at 30, 60, and 90 days follow-up. The study will evaluate changes in HIV testing behavior and the number of risky sexual partnerships from the beginning to the end of the study.

Official TitleDevelopment of a Tailored HIV Prevention Intervention for Young Men
R34MH101997NCT02842060
Principal SponsorUniversity of Pennsylvania
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

180 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Prevention Study

Prevention studies aim to stop a disease from developing. They often involve people at risk and test things like vaccines, lifestyle changes, or preventive medications.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Male

Biological sex of participants that are eligible to enroll.

From 18 to 24 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Blood-Borne InfectionsUrogenital DiseasesGenital DiseasesCommunicable DiseasesImmunologic Deficiency SyndromesImmune System DiseasesInfectionsRetroviridae InfectionsRNA Virus InfectionsSexually Transmitted DiseasesVirus DiseasesSexually Transmitted Diseases, ViralHIV InfectionsLentivirus Infections

Criteria

6 inclusion criteria required to participate
Cis-gender male
Self-report as being single
Self report as HIV-negative at baseline
Speak and read English
Show More Criteria
4 exclusion criteria prevent from participating
Transgender identity
HIV positive diagnosis
Not residing in the United States
Does not engage in male-to-male sexual behavior

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
The proposed intervention will consist of a 6-session web-based program. Cognizant of challenges maintaining users' attention in a web application and to facilitate delivery through a smartphone, the investigators will design each session to be no more than 20 minutes in length. In the course of these 6 sessions, YMSM will have a total of 120 minutes of intervention exposure. Across sessions, the investigators will emphasize the importance of sexual decision-making across different partner types, help YMSM consider what type of relationship(s) they want, and align these relationship desires with safer sex practices.

Group II

Active Comparator
The investigators will create a 6-session web-based attention-control comparison to match myDEx in time and attention yet have non-tailored and non-interactive content (NTHP). NTHP will include HIV/STI information currently available on sex education websites.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

University of Pennsylvania

Philadelphia, United StatesOpen University of Pennsylvania in Google Maps
CompletedOne Study Center