Completed

Effectiveness of an Educational Physiotherapy and Home Exercises Program in Adult Patients With Hemophilia: A Randomized Clinical Trial

What is being tested

Educational physiotherapy group

Other

Who is being recruted

Behavior+12

+ Blood Coagulation Disorders

+ Hematologic Diseases

Over 18 Years

+7 Eligibility Criteria

See all eligibility criteria

How is the trial designed

Treatment Study

Interventional

Study Start: February 2012

See protocol details

Summary

Principal SponsorReal Fundación Victoria Eugenia

Last updated: January 27, 2026

Sourced from a government-validated database.Claim as a partner

Study start date: February 1, 2012

Actual date on which the first participant was enrolled.

Although arthropathy is a serious problem in patients with hemophilia due to the associated morbidity and incapacity, to the best of the investigators knowledge, no studies have looked at the effect of educational physiotherapy for its clinical improvement. This contribution presents the results of educational physiotherapy program applied for 15 weeks with home exercises - in patients with hemophilic arthropathy. After treatment, experimental group showed improved a significant reduction of pain, and best quality of life al illness behaviour. During treatment no patient showed elbow haemarthrosis, which underlines the safety of this physiotherapy program.

Official TitleEffectiveness of an Educational Physiotherapy and Home Exercises Program in Adult Patients With Hemophilia: A Randomized Clinical Trial

NCT02825706

Principal SponsorReal Fundación Victoria Eugenia

Last updated: January 27, 2026

Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Design Details

20 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.

Conditions

Criteria

Male

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

BehaviorBlood Coagulation DisordersHematologic DiseasesHemic and Lymphatic DiseasesHemophilia AHemorrhagic DisordersCongenital, Hereditary, and Neonatal Diseases and AbnormalitiesNeurologic ManifestationsPainSigns and SymptomsPathological Conditions, Signs and SymptomsCoagulation Protein DisordersBlood Coagulation Disorders, InheritedGenetic Diseases, InbornIllness Behavior

Criteria

4 inclusion criteria required to participate

Patients diagnosed with hemophilia A or B

Patients over 18 years

Patients with hemophilic arthropathy with at least 1 involved joint (elbow, knee or ankle)

having signed the informed consent document.

3 exclusion criteria prevent from participating

Patients diagnosed with other congenital bleeding disorders (i.e. von Willebrand disease)

Patients who developed antibodies to FVIII or FIX (inhibitors)

Those not able to ambulate as a result of hemophilic arthropathy or any other disability

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.

Treatment Groups

Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group

Treatment Groups

Group I

Experimental

The patients in experimental group received 60-minute educational sessions every two weeks about the pathophysiology of hemophilia, clinical manifestations, postural advice and prevention advice to avoid recurrent bleeding. Likewise, doubts on the clinical progress of hemophilic arthropathy, functional limitations and management of joint pain were resolved. In parallel with the educational sessions, patients followed a 15-week home exercise program performed once a day, 6 days a week. The program included muscle stretching exercises; isometric exercises; proprioceptive exercises on one leg with visual support; and a 20-minute walk. Low-intensity exercises with 20-25 repetitions were included.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

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CompletedNo study centers