Suspended

Beta-alanine Supplementation and Its Effects on Performance, Muscle Carnosine Content and Safety in Athletes With Spinal-cord Injury

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What is being tested

Beta-alanine

+ Dextrose

Dietary Supplement
Who is being recruted

Central Nervous System Diseases+3

+ Nervous System Diseases

+ Spinal Cord Diseases

From 18 to 40 Years
+8 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Placebo-Controlled
Interventional
Study Start: February 2016
See protocol details

Summary

Principal SponsorUniversity of Sao Paulo
Study ContactGuilherme Artioli, PhD
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: February 1, 2016

Actual date on which the first participant was enrolled.

Paralympians competing in wheelchair sports may experience a very high glycolytic demand (and therefore acidotic environment) in their upper-body muscles, particularly in high-intensity disciplines. Previous studies from our group have shown that upper-body exercise is very sensitive to the ergogenic effects of β-alanine supplementation and to other nutritional supplements capable of increasing buffering capacity. In line with this, have shown that upper-body muscle groups benefit more from artificially induced alkalosis than lower-body muscle groups. Although β-alanine appears to be an interesting and potential ergogenic supplement for paralympians, no study to date has assessed its potential in wheelchair athletes.In this study, we will evaluate the effects of β-alanine supplementation on upper-body performance in wheelchair athletes.

Official TitleBeta-alanine Supplementation and Its Effects on Performance, Muscle Carnosine Content and Safety in Athletes With Spinal-cord Injury
NCT02604927
Principal SponsorUniversity of Sao Paulo
Study ContactGuilherme Artioli, PhD
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

20 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Male

Biological sex of participants that are eligible to enroll.

From 18 to 40 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Central Nervous System DiseasesNervous System DiseasesSpinal Cord DiseasesSpinal Cord InjuriesWounds and InjuriesTrauma, Nervous System

Criteria

4 inclusion criteria required to participate
Paralympian training for any exercise modality for at least one year;

A weekly training volume of 6 hours or more;

Have a spinal cord injury accompanied by loss of motor function in the lower limbs for at least one year;

Available for carrying out the experimental procedures.

4 exclusion criteria prevent from participating
Use of creatine or beta-alanine for at least 3 and 6 months before the trial;

Cardiovascular or respiratory disease;

Clinical condition that result in malabsorption of nutrients;

Any other medical condition that prevents the realization of experimental procedures.

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

50% chance of being blinded to the placebo group

Treatment Groups

Group I

Experimental
800 mg of beta-alanine, four times per day, during 28 days.

Group II

Placebo
800 mg of dextrose, four times per day, during 28 days.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

School of Physical Education and Sports, University of Sao Paulo

São Paulo, BrazilOpen School of Physical Education and Sports, University of Sao Paulo in Google Maps
SuspendedOne Study Center