Recruiting

CUVIA-AF IIClinical Usefulness of Virtual Ablation Guided Catheter Ablation of Atrial Fibrillation: Virtual Rotor Mapping and Catheter Ablation

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What is being tested

physician's personal experience

+ Virtual rotor mapping

Procedure
Who is being recruted

Arrhythmias, Cardiac+3

+ Atrial Fibrillation

+ Cardiovascular Diseases

From 19 to 80 Years
+9 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: August 2018
See protocol details

Summary

Principal SponsorYonsei University
Study ContactHui-Nam Pak
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: August 24, 2018

Actual date on which the first participant was enrolled.

Radiofrequency catheter ablation is effective in the treatment of patients with paroxysmal atrial fibrillation. In order to reduce the recurrence rate after catheter ablation, the investigators propose to apply 'virtual' ablation on patient-specific atria by simulating 3D atrial computer model. The investigators will conduct virtual rotor mapping in the patient specific atrial model. Then, the investigators will compare the clinical outcome of conventional circumferential pulmonary vein isolation and additional rotor ablation guided by virtual rotor mapping.

Official TitleClinical Usefulness of Virtual Ablation Guided Catheter Ablation of Atrial Fibrillation: Virtual Rotor Mapping and Catheter Ablation
NCT02558699
Principal SponsorYonsei University
Study ContactHui-Nam Pak
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

110 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 19 to 80 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Arrhythmias, CardiacAtrial FibrillationCardiovascular DiseasesHeart DiseasesPathologic ProcessesPathological Conditions, Signs and Symptoms

Criteria

2 inclusion criteria required to participate
AF patient age 19~80
Diagnosis of AF patients who performed catheter ablation of atrial fibrillation due to uncontrolled pulse rate by anti-arrhythmic drug therapy.
7 exclusion criteria prevent from participating
AF patients who have severe heart deformations or vascular disease.
The patient who have renal disease of eGFR<30mL/min
The patients who had been performed catheter ablation of atrial ablation and MAZE.
The patients who missed out to recording of 3D CT, echo and electrocardiography.
Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Active Comparator
Group operating the atrial fibrillation by physician's personal experience, not by virtual simulation.

Group II

Experimental
Group choosing choose the best effective rotor mapping by simulating 3D atrial computer model which consider patinet's heart size and shape.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

Severance Cardiovascular Hospital, Yonsei University Health System

Seoul, South KoreaOpen Severance Cardiovascular Hospital, Yonsei University Health System in Google Maps
Recruiting
One Study Center
CUVIA-AF II | Clinical Usefulness of Virtual Ablation Guided Catheter Ablation of Atrial Fibrillation: Virtual Rotor Mapping and Catheter Ablation | PatLynk