Completed

COLINInterest of COLchicine in the Treatment of Patients With Acute Myocardial INfarction and With Inflammatory Response

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What is being tested

Colchimax®

+ Conventional treatment

Drug
Who is being recruted

Inflammation

+ Pathologic Processes

+ Pathological Conditions, Signs and Symptoms

From 18 to 90 Years
+22 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Phase 2
Interventional
Study Start: December 2014
See protocol details

Summary

Principal SponsorUniversity Hospital, Montpellier
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: December 1, 2014

Actual date on which the first participant was enrolled.

Background: Colchicine is an old well-known venerable drug routinely used in gout attacks for instance. More recnetly it is regularly use in the treatment of pericarditis. It couls exert antiiflammatory effects targeting the adverse inflammation occuring incase of acute myocardial infarction, which is involved in poor outcomes or longer stay at hospital. Endpoints: * Main endpoint: AUC CRP during the initial hospital stay * Secondary endpoints: * Clinical: oucomes * Imaging: ETT, MRI * Biological: various biomarkers Method Randomized, controled, open-labbelled, comparing two parallel arms: conventionnal optimal treatment versus conventionnal optimal treatment + colchicine

Official TitleInterest of COLchicine in the Treatment of Patients With Acute Myocardial INfarction and With Inflammatory Response
NCT02363725
Principal SponsorUniversity Hospital, Montpellier
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

44 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 90 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

InflammationPathologic ProcessesPathological Conditions, Signs and Symptoms

Criteria

5 inclusion criteria required to participate
Acute myocardial inflarction (occlusion of coronary artery as assessed on the coronaro angiogram)
Adult (18-90y)
Men / women
Aigned informed consent
Show More Criteria
17 exclusion criteria prevent from participating
Cardiogenic shock
Digestive troubles
Active bowels inflammatory disease (Crhon, chronic, diarrhea...)
Intolerance to the drug
Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
Optimal conventional treatment + Colchimax®

Group II

Optimal conventional treatment used for patients admitted for STEMI (ESC guidelines 2012): * Double anti-aggregation * IEC (or sartan) at best tolerated dose * Beta-blocker at best tolerated dose * High dose statin (usually atorvastatin 80 mg daily) * If ventricular dysfunction; inhibitor minérolcorticoïdes (the eplerenone more often) * Any other treatment will be logged.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

University Hospital Arnaud de Villeneuve

Montpellier, FranceOpen University Hospital Arnaud de Villeneuve in Google Maps
CompletedOne Study Center