Suspended

The Effect of Branched-chain Amino Acid (BCAA) on the Progression of Primary Liver Cancer

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What is being tested

Branched-chain amoni acids (BCAA)

+ non-BCAA protein supplement

Dietary Supplement
Who is being recruted

Adenocarcinoma+8

+ Carcinoma

+ Digestive System Diseases

From 18 to 65 Years
+8 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Placebo-Controlled
Interventional
Study Start: January 2015
See protocol details

Summary

Principal SponsorTel-Aviv Sourasky Medical Center
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: January 1, 2015

Actual date on which the first participant was enrolled.

Supplementation of BCAA found to reduce the risk of developing liver cancer, but the affect of BCAA on existing liver cancer is unknown. The participants (post curative intent surgery) will be supplemented with either BCAA/non-BCAA-enriched protein supplement. The intervantion will go on for 2 years or until a new liver tumor is found.

Official TitleThe Effect of Branched-chain Amino Acid (BCAA) on the Progression of Primary Liver Cancer
NCT02327819
Principal SponsorTel-Aviv Sourasky Medical Center
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

60 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 65 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

AdenocarcinomaCarcinomaDigestive System DiseasesDigestive System NeoplasmsCarcinoma, HepatocellularLiver DiseasesLiver NeoplasmsNeoplasmsNeoplasms by Histologic TypeNeoplasms by SiteNeoplasms, Glandular and Epithelial

Criteria

4 inclusion criteria required to participate
diagnosed primary liver cancer

viral or Nonalcoholic Steatohepatitis Cirrhosis

Cirrhosis rated Child-Pugh A

liver cancer rated Barcelona Clinic Liver Cancer (BCLC) A

4 exclusion criteria prevent from participating
Age (over 65)

liver condition rated Child-Pugh B/C

GI/Absorption issues

patients given a treatment before surgery

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

50% chance of being blinded to the placebo group

Treatment Groups

Group I

Active Comparator
Branched-chain amino acids supplement, 12 g/day

Group II

Sham
non-BCAA protein supplement

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Clinical Nutrition Unit, Sourasky Medical Center

Tel Aviv, IsraelOpen Clinical Nutrition Unit, Sourasky Medical Center in Google Maps
SuspendedOne Study Center