Suspended

Effect of Amantadine Administration on Spatial Functioning Following Traumatic Brain Injury

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What is being tested

Amantadine hydrochloride

Drug
Who is being recruted

Brain Injuries, Traumatic+5

+ Brain Diseases

+ Brain Injuries

From 18 to 50 Years
+9 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Phase 4
Interventional
Study Start: June 2014
See protocol details

Summary

Principal SponsorLoewenstein Hospital
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: June 1, 2014

Actual date on which the first participant was enrolled.

Amantadine hydrochloride is one of the drugs given at rehabilitation programs to people who suffered Acquired Brain Injury in order to expedite recovery and improve functioning. A previous study examined the spatially asymmetric allocation of attention in patients with traumatic brain injury (TBI). Patients demonstrated significantly worse performance with leftward than with rightward cross-hemi field shifts of attention. This is reminiscence of neglect patients. This difference was significantly reduced during and following treatment. Our objective is to investigate whether Amantadine Hydrochloride is effective in improving allocation of spatial attention and improving function in people with Traumatic Brain Injury.

Official TitleEffect of Amantadine Administration on Spatial Functioning Following Traumatic Brain Injury
NCT02321761
Principal SponsorLoewenstein Hospital
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

10 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 50 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Brain Injuries, TraumaticBrain DiseasesBrain InjuriesCentral Nervous System DiseasesCraniocerebral TraumaNervous System DiseasesWounds and InjuriesTrauma, Nervous System

Criteria

5 inclusion criteria required to participate
Aged 18-50 yrs
Patients who were diagnosed with a Diffuse Axonal Injury post TBI
Severity of injury was defined as moderate to severe
At least 3 months post injury
Show More Criteria
4 exclusion criteria prevent from participating
Pyramidal signs on neurological examination
Localised damage demonstrated on CT
Contra indication to Amantadine, post traumatic epilepsy, renal failure and patients with known sensitivity to Amantadine
Patients who were diagnosed with Parkinson's disease or has a first degree family who was diagnosed with Parkinson's.

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
Dosage (mg) Day days 0-14 no drug will be given days 15-21 dosage is 100 mg days 22-28 dosage is 200mg days 29-42 dosage is 400mg days 43-56 dosage is 200mg days 57-70 no drug will be given

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

Loewenstein Rehabilitation Center

Raanana, IsraelOpen Loewenstein Rehabilitation Center in Google Maps
SuspendedOne Study Center