Completed

Aerobic Interval-Training's Impact on Glycemic Control and Systemic Inflammation in Type 2 Diabetes

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Study Aim

This study aims to evaluate how Aerobic Interval-Training can improve glycemic control and reduce systemic inflammation in individuals with Type 2 Diabetes, using continuous glucose monitoring over 24 hours.

What is being tested

Control

+ Continuous walking

+ Interval walking

Behavioral
Who is being recruted

Behavior+7

+ Diabetes Mellitus

+ Diabetes Mellitus, Type 2

Over 40 Years
+8 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: November 2014
See protocol details

Summary

Principal SponsorRigshospitalet, Denmark
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: November 1, 2014

Actual date on which the first participant was enrolled.

Interval training is superior to continuous training for improving glycemic control, hereunder glycemic variability and -spikes. However, the underlying mechanisms and the clinical impact is at present unknown. The overall objective of this project is to determine the mechanisms underlying aeroic interval-training-induced reductions in glycemic variability and -spikes, and the impact on levels of systemic inflammation in type 2 diabetes patients. It is hypothesized that aerobic interval training reduces glycemic variability and -spikes more than continuous training due to larger improvements in both peripheral insulin sensitivity and the mass action effect of glucose. Moreover, it is hypothesized that these reductions in glycemic variability and -spikes also reduces systemic inflammation.

Official TitleInterval-training in Type 2 Diabetics - Mechanisms Behind Increased Glucose Disposal and Effects on Systemic Inflammation
NCT02320526
Principal SponsorRigshospitalet, Denmark
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

14 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 40 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

BehaviorDiabetes MellitusDiabetes Mellitus, Type 2Endocrine System DiseasesHyperinsulinismInsulin ResistanceMetabolic DiseasesMotor ActivityNutritional and Metabolic DiseasesGlucose Metabolism Disorders

Criteria

2 inclusion criteria required to participate
Type 2 diabetes mellitus
BMI >18 but <40 kg/m2
6 exclusion criteria prevent from participating
Pregnancy
Smoking
Contraindication to increased levels of physical activity
More than moderate levels of physical activity (>90 min/week) of maximally moderate intensity
Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

3 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
Control intervention: Subjects will continue their life unaltered during the 14 days intervention period

Group II

Experimental
Training intervention: Subjects will perform continuous walking for one hour per day at every weekday during the 14 days intervention period

Group III

Experimental
Training intervention: Subjects will perform interval walking for one hour per day at every weekday during the 14 days intervention period. Interval walking will be performed as repeated cycles of three minutes of slow and hree minutes of fast walking during the entire training session

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

The Centre for Physical Activity Research, Rigshospitalet

Copenhagen, DenmarkOpen The Centre for Physical Activity Research, Rigshospitalet in Google Maps
CompletedOne Study Center