Suspended

Albuterol and Dynamic Hyperinflation in Idiopathic Pulmonary Arterial Hypertension

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What is being tested

Albuterol.

+ Normal saline placebo

Drug
Who is being recruted

Hypertension, Pulmonary+1

+ Lung Diseases

+ Respiratory Tract Diseases

From 18 to 75 Years
+15 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Placebo-ControlledPhase 2
Interventional
Study Start: June 2014
See protocol details

Summary

Principal SponsorAmerican Medical Association Foundation
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: June 1, 2014

Actual date on which the first participant was enrolled.

Only a few small studies have evaluated the relationship between iPAH, expiratory flow limitation, and exercise dyspnea. While not all patients with iPAH demonstrate airway involvement, those who demonstrate dynamic hyperinflation (DH), defined as a variable and temporary increase in end-expiratory lung volume, report increased dyspnea with exertion on maximal testing. There is a continued need for adjuvant therapy in iPAH, and bronchodilators have the potential to ameliorate dyspnea during exercise, which could lead to improved quality of life in this disabling condition. This study will investigate the presence of airway involvement in this population as measured by dynamic hyperinflation, and if there is any improvement in function with the use of inhaled albuterol.

Official TitleAlbuterol and Dynamic Hyperinflation in Idiopathic Pulmonary Arterial Hypertension
NCT02108743
Principal SponsorAmerican Medical Association Foundation
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 75 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Hypertension, PulmonaryLung DiseasesRespiratory Tract DiseasesFamilial Primary Pulmonary Hypertension

Criteria

3 inclusion criteria required to participate
18 years of age or greater.
Idiopathic Pulmonary Arterial Hypertension, or Familial Pulmonary Arterial Hypertension.
Forced expiratory flow 75% (FEF75%) of ≤ 65% of predicted.
12 exclusion criteria prevent from participating
Clinical instability or change in medication therapy in preceding 3 months.
Allergy or intolerance to inhaled albuterol.
Body mass index > 30
Active tobacco use, or > 10 pack-year smoking history.
Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

50% chance of being blinded to the placebo group

Treatment Groups

Group I

Active Comparator
2.5 mg of albuterol inhaled via jet nebulizer 15 minutes prior to symptom-limited maximal CPET.

Group II

Placebo
Normal saline placebo inhaled via jet nebulizer 15 minutes prior to symptom-limited maximal CPET.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

LSUHSC Interim Louisiana Hospital

New Orleans, United StatesOpen LSUHSC Interim Louisiana Hospital in Google Maps
SuspendedOne Study Center