Completed

SteroidThe Use of Perioperative Steroids in Patients Undergoing Transsphenoidal Resection of Pituitary Tumors or Cysts

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What is being tested

hydrocortisone

+ dexamethasone

Drug
Who is being recruted

Brain Diseases+12

+ Brain Neoplasms

+ Central Nervous System Diseases

Over 18 Years
+5 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: March 2012
See protocol details

Summary

Principal SponsorWashington University School of Medicine
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: March 1, 2012

Actual date on which the first participant was enrolled.

Patients who are scheduled to undergo transsphenoidal resection for a pituitary tumor or cyst at the investigators institution will be screened prior to surgery for eligibility for this study. All patients deemed eligible will undergo a cosyntropin stimulation test to evaluate for adrenal insufficiency. Patients with adrenal insufficiency will be excluded from the study.

Official TitleThe Use of Perioperative Steroids in Patients Undergoing Transsphenoidal Resection of Pituitary Tumors or Cysts
NCT02084134
Principal SponsorWashington University School of Medicine
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

43 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.


Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Brain DiseasesBrain NeoplasmsCentral Nervous System DiseasesEndocrine System DiseasesEndocrine Gland NeoplasmsHypothalamic DiseasesHypothalamic NeoplasmsNeoplasmsNeoplasms by SiteNervous System DiseasesNervous System NeoplasmsPituitary DiseasesPituitary NeoplasmsSupratentorial NeoplasmsCentral Nervous System Neoplasms

Criteria

1 inclusion criteria required to participate
Any adult patient with a pituitary adenoma or cyst (either non-functioning, prolactin secreting, growth hormone secreting, gonadotropin secreting, or TSH (Thyrotropin secreting hormone) scheduled to undergo transsphenoidal resection.

4 exclusion criteria prevent from participating
Patients with Cushing's Disease (pituitary tumor which secretes ACTH)

Patients with a history of pituitary apoplexy (condition caused by hemorrhage into a pituitary adenoma which causes headache, double vision and hypopituitarism)

Patients on long term glucocorticoid therapy

Patients with adrenal insufficiency or who have not had their adrenal response evaluated prior to surgery

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Active Comparator
Receives intravenous hydrocortisone 100mg and following surgery intravenous dexamethasone 0.5mg

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Washington University School of Medicine

St Louis, United StatesOpen Washington University School of Medicine in Google Maps
CompletedOne Study Center
Steroid | The Use of Perioperative Steroids in Patients Undergoing Transsphenoidal Resection of Pituitary Tumors or Cysts | PatLynk