Completed

epipericardialEpipericardial Fat Necrosis: A Misdiagnosed Condition

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What is being collected

Data Collection

Collected at a single point in time - Cross-sectional
Who is being recruted

Chest Pain+5

+ Fat Necrosis

+ Necrosis

+2 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Case-Crossover

Comparing exposures during disease occurrence and non-occurrence in order to assess the short-term effects of triggers.
Observational
Study Start: June 2013
See protocol details

Summary

Principal SponsorHospital Sirio-Libanes
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: June 1, 2013

Actual date on which the first participant was enrolled.

Epipericardial fat necrosis is a benign and self-limited condition that mainly curses with acute pleuritic chest pain and therefore must be an important differential diagnosis for patients in emergency department (ED). The knowledge of characteristics symptoms and correct management may avoid misdiagnosis or mistakes with other severe conditions like pulmonary embolism, pericarditis or acute coronary disease. Despite the importance of this entity, only fewer than 40 cases have been reported since 1957, when the condition was first described. We have seen a couple of similar cases in our institution during a short period of time, and we suspect that these numbers doesn't mean the real prevalence of epipericardial fat necrosis, so maybe this condition could be underdiagnosed. Instead, there isn't a study that tried to estimate an incidence of this entity.

Official TitleEpipericardial Fat Necrosis: A Misdiagnosed Condition
NCT01903980
Principal SponsorHospital Sirio-Libanes
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

10 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Case-Crossover

In this design, participants serve as their own control. Researchers compare a person's exposures just before a health event with exposures at other times, helping identify short-term triggers or risk factors.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Chest PainFat NecrosisNecrosisNeurologic ManifestationsPainPathologic ProcessesSigns and SymptomsPathological Conditions, Signs and Symptoms

Criteria

1 inclusion criteria required to participate
patients with imaging criteria of EFN (defined as a round fat attenuation lesion with peripheral stranding located in the epipericardial fat)
1 exclusion criteria prevent from participating
no exclusion criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Study Objectives

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 2 locations

Suspended

Hospital Sirio Libanes

São Paulo, BrazilOpen Hospital Sirio Libanes in Google Maps
Suspended

Hospital Sirio-Libanes

São Paulo, Brazil
Completed2 Study Centers