Completed

Transcranial Magnetic Stimulation Treatment for Generalized Anxiety Disorder

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What is being tested

TMS

Device
Who is being recruted

Generalized Anxiety Disorder

+ Anxiety Disorders

+ Mental Disorders

Over 18 Years
+17 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Placebo-Controlled
Interventional
Study Start: May 2012
See protocol details

Summary

Principal SponsorHartford Hospital
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: May 1, 2012

Actual date on which the first participant was enrolled.

Participants will complete structural MRI for neuronavigation. Participants will be randomly assigned to treatment condition. TMS or Sham-TMS sessions will occur daily 5 days/week for 6 weeks. Assessments will occur at pretreatment, weekly during treatment, post-treatment, and 3 month.

Official TitleTranscranial Magnetic Stimulation Treatment for Generalized Anxiety Disorder
NCT01659736
Principal SponsorHartford Hospital
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

26 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Generalized Anxiety DisorderAnxiety DisordersMental Disorders

Criteria

6 inclusion criteria required to participate
Fluency in English
Diagnosed with GAD as the principal or co-principal disorder
Clinical Global Impression Score ≥ 4
Hamilton Anxiety Rating Scale ≥ 18
Show More Criteria
11 exclusion criteria prevent from participating
History of epilepsy or head trauma (LOC > 5 minutes) within the past 6 months.
Lifetime history of increased intracranial pressure, seizure disorder, stroke, brain tumor, multiple sclerosis, or brain surgery.
A review of patient medications by the study physician indicates an increased risk of seizure.
An active autoimmune, endocrine, viral, or vascular disorder affecting the brain; any unstable cardiac disease; hypertension; or severe renal or liver insufficiency.
Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

50% chance of being blinded to the placebo group

Treatment Groups

Group I

Experimental
TMS treatment

Group II

Sham
This is a sham TMS condition

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Hartford Hospital

Hartford, United StatesOpen Hartford Hospital in Google Maps
CompletedOne Study Center