Suspended

VitCThe Efficacy of High Dose Vitamin C in the Critically Ill Patient Population

What is being tested

Ascorbic Acid

+ Ringers Lactate or Normal Saline

DrugOther

Who is being recruted

Pathologic Processes+1

+ Shock

+ Pathological Conditions, Signs and Symptoms

Over 18 Years

+10 Eligibility Criteria

See all eligibility criteria

How is the trial designed

Prevention Study

Placebo-ControlledPhase 2

Interventional

Study Start: February 2013

See protocol details

Summary

Principal SponsorRutgers, The State University of New Jersey

Last updated: January 27, 2026

Sourced from a government-validated database.Claim as a partner

Study start date: February 1, 2013

Actual date on which the first participant was enrolled.

It has been shown that the stress that occurs during trauma, infection and/or shock depletes many of the body's resources such as Vitamin C (ascorbic acid) which may contribute to further complications. The purpose of this study is to determine the effectiveness of high doses of Vitamin C in critically ill patients.

Official TitleThe Efficacy of High Dose Vitamin C in the Critically Ill Patient Population

NCT01587963

Principal SponsorRutgers, The State University of New Jersey

Last updated: January 27, 2026

Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Design Details

11 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Prevention Study

Prevention studies aim to stop a disease from developing. They often involve people at risk and test things like vaccines, lifestyle changes, or preventive medications.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.

Conditions

Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Pathologic ProcessesShockPathological Conditions, Signs and SymptomsHypovolemia

Criteria

2 inclusion criteria required to participate

Activation of the Mass Transfusion Protocol following surgery or trauma.

Diagnosis of septic shock. Septic shock will be defined as sepsis induced hypotension (i.e. systolic blood pressure <90mmHg or drop of systolic blood pressure >40mmHg in the presence of infection) that does not respond to a 2 liter fluid bolus.

8 exclusion criteria prevent from participating

History of liver cirrhosis

Age less than 18 years.

Pregnant women.

Creatinine of greater than 2.2 g/dl at time of enrollment, history of chronic kidney or end stage renal disease, rise in creatinine > 1 g/dl within 24 hours prior to enrollment.

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.

Treatment Groups

Study Objectives

2 intervention groups are designated in this study

50% chance of being blinded to the placebo group

Treatment Groups

Group I

Active Comparator

Ascorbic Acid

Group II

Placebo

Ringers Lactate or Normal Saline

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Robert Wood Johnson University Hospital

New Brunswick, United StatesOpen Robert Wood Johnson University Hospital in Google Maps

SuspendedOne Study Center