Completed

FREEDOMThe Gore FREEDOM Study: GORE Flow Reversal System and GORE Embolic Filter Extension Study for the Ongoing Collection of Patient Outcomes

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What is being tested

Gore Flow Reversal System

+ Gore Embolic Filter

Device
Who is being recruted

Arterial Occlusive Diseases+9

+ Brain Diseases

+ Cardiovascular Diseases

Over 18 Years
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: April 2011
See protocol details

Summary

Principal SponsorW.L.Gore & Associates
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: April 1, 2011

Actual date on which the first participant was enrolled.

Physicians will have the opportunity to select which embolic protection device, the GORE Flow Reversal System or the GORE Embolic Filter, to use during the carotid artery stenting procedure. This study is not designed to compare study endpoints between the two treatment arms.

Official TitleThe Gore FREEDOM Study: GORE Flow Reversal System and GORE Embolic Filter Extension Study for the Ongoing Collection of Patient Outcomes
NCT01343667
Principal SponsorW.L.Gore & Associates
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

1397 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Arterial Occlusive DiseasesBrain DiseasesCardiovascular DiseasesCarotid Artery DiseasesCentral Nervous System DiseasesCerebrovascular DisordersConstriction, PathologicNervous System DiseasesPathological Conditions, Signs and SymptomsVascular DiseasesCarotid StenosisPathological Conditions, Anatomical

Criteria

Inclusion Criteria: * Patient, or patient's legal representative, is able and willing to provide informed consent. * Patient must be at least 18 years of age or older. * Patient will be selected and treated according to the GORE Flow Reversal System Instructions for Use (IFU) or the GORE Embolic Filter IFU. Exclusion Criteria: * Patient is contraindicated for the embolic protection device arm they are selected by the investigator to receive: Either Per the GORE Flow Reversal System IFU if the GORE Flow Reversal System is selected OR Per the GORE Embolic Filter IFU if the GORE Embolic Filter is selected If the patient is contraindicated for both arms (devices) they may not be enrolled.

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Carotid artery stenting with Gore Flow Reversal System embolic protection device

Group II

Carotid artery stenting with Gore Embolic Filter embolic protection device

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 39 locations

Suspended

W.L. Gore and Associates, Inc

Flagstaff, United StatesOpen W.L. Gore and Associates, Inc in Google Maps
Suspended

Hoag Memorial Hospital

Newport Beach, United States
Suspended

University of California San Francisco

San Francisco, United States
Suspended

First Coast Cardiovascular Institute

Jacksonville, United States
Completed39 Study Centers