Completed

Physical Activity in Overweight Girls: Implications for Reversing Risk Factors for Type 2 Diabetes

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What is being tested

Control

+ Resistance Exercise

+ Aerobic exercise

Other
Who is being recruted

Behavior+16

+ Body Weight

+ Digestive System Diseases

From 12 to 18 Years
+11 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: August 2010
See protocol details

Summary

Principal SponsorUniversity of Pittsburgh
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: August 1, 2010

Actual date on which the first participant was enrolled.

In this randomized controlled trial, we will examine the effect of a 3-month exercise training (aerobic exercise versus resistance exercise) without calorie restriction on total and regional adiposity, ectopic fat in the liver and skeletal muscle, and risk of type 2 diabetes in overweight girls.

Official TitlePhysical Activity in Overweight Girls: Implications for Reversing Risk Factors for Type 2 Diabetes
1R21DK083654-01A1NCT01323088
Principal SponsorUniversity of Pittsburgh
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

44 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Female

Biological sex of participants that are eligible to enroll.

From 12 to 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

BehaviorBody WeightDigestive System DiseasesFatty LiverHyperinsulinismInsulin ResistanceLiver DiseasesMetabolic DiseasesMotor ActivityNutrition DisordersNutritional and Metabolic DiseasesObesitySigns and SymptomsPathological Conditions, Signs and SymptomsOvernutritionGlucose Metabolism DisordersOverweightObesity, AbdominalPediatric Obesity

Criteria

5 inclusion criteria required to participate
Healthy overweight (BMI >-95th) youth between 12 and 18 years of age
Waist circumference >-75th percentile
Sedentary (no structured exercise >2 times/week for past 6 months)
Non-smokers, non-diabetic, no medical conditions
Show More Criteria
6 exclusion criteria prevent from participating
Smokers
Diabetes
Psychiatric disorders
Syndromic obesity
Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

3 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Standard care control (no-exercise)

Group II

Active Comparator

Group III

Active Comparator

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine

Pittsburgh, United StatesOpen Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine in Google Maps
CompletedOne Study Center