Completed

CArDiAXThe Safety and Feasibility of Delivering Xenon to Patients Before and After Coronary Artery Bypass Graft Implantation: a Pilot Study

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What is being tested

Xenon

+ Sevoflurane

Drug
Who is being recruted

Cardiovascular Diseases+7

+ Coronary Disease

+ Heart Diseases

Over 50 Years
+25 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Phase 3
Interventional
Study Start: May 2011
See protocol details

Summary

Principal SponsorRWTH Aachen University
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: May 1, 2011

Actual date on which the first participant was enrolled.

The study will be conducted by two investigator types: The study enrollment and the post-anesthesia follow-up will be performed by Investigator I who is blinded to the study treatment. Investigator II will only perform general anaesthesia for CABG surgery and will therefore necessarily be unblinded to the treatment conditions. Patients will be randomly assigned to one of the following study groups. Group 1 (Xenon) will receive xenon for maintenance of balanced anesthesia for CABG surgery before and after extracorporal circulation. Group 2 (Sevoflurane) will receive sevoflurane for maintenance of balanced anesthesia for CABG surgery before and after extracorporal circulation. During extracorporal circulation, general anesthesia will be maintained intravenously in both groups.

Official TitleThe Safety and Feasibility of Delivering Xenon to Patients Before and After Coronary Artery Bypass Graft Implantation: a Pilot Study
NCT01285271
Principal SponsorRWTH Aachen University
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

30 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 50 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Cardiovascular DiseasesCoronary DiseaseHeart DiseasesPathologic ProcessesRespiration DisordersRespiratory Tract DiseasesPathological Conditions, Signs and SymptomsVascular DiseasesMyocardial IschemiaRespiratory Aspiration

Criteria

7 inclusion criteria required to participate
women without childbearing potential
ASA Score II-IV
men and women >= 50 yrs
Patients with coronary artery disease scheduled for elective CABG
Show More Criteria
18 exclusion criteria prevent from participating
Lack of informed consent
EuroSCORE < 8
MMSE < 24
Age < 50 years
Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
Xenon will be administered for balanced general anesthesia for CABG surgery before and after the extracorporal circulation.

Group II

Active Comparator
Sevoflurane will be administered for balanced general anesthesia for CABG surgery before and after the extracorporal circulation.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Department of Anesthesiology, University Hospital Aachen

Aachen, GermanyOpen Department of Anesthesiology, University Hospital Aachen in Google Maps
CompletedOne Study Center