Completed

Absorption of "ABH Gel" (Ativan®, Lorazepam; Benadryl®, Diphenhydramine; and Haldol®, Haloperidol Gel) From the Skin of Normal Volunteers

0 criteria met from your profileSee at a glance how your profile meets each eligibility criteria.
What is being tested

lorazepam

+ diphenhydramine hydrochloride

+ haloperidol

DrugOther
Who is being recruted

Over 18 Years
+8 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Supportive Care Study

Interventional
Study Start: November 2010
See protocol details

Summary

Principal SponsorVirginia Commonwealth University
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: November 15, 2010

Actual date on which the first participant was enrolled.

OBJECTIVES:I. To study the absorption of the three components in the topical ABH gel in 10 healthy volunteers, and determine if there are any adverse effects. OUTLINE: Patients apply lorazepam, diphenhydramine hydrochloride, and haloperidol gel topically over 2 minutes. After completion of study treatment, patients are followed up for 5 hours.

Official TitleAbsorption of "ABH Gel" (Ativan®, Lorazepam; Benadryl®, Diphenhydramine; and Haldol®, Haloperidol Gel) From the Skin of Normal Volunteers
NCT01204255
Principal SponsorVirginia Commonwealth University
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

11 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Supportive Care Study

These studies explore ways to improve comfort and daily life for people living with a condition. They may focus on easing symptoms, reducing treatment side effects, or supporting overall well-being.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

5 inclusion criteria required to participate
Completed a medical screening questionnaire
English speaking
No allergies to the drugs
Able to complete the forms
Show More Criteria
3 exclusion criteria prevent from participating
History of substance abuse, psychiatric disorder, acquired brain injury, the possibility of pregnancy (not using birth control, and of child bearing age)
Use of any medication that would contraindicate benzodiazepine administration
Pregnant or nursing

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
Patients apply lorazepam, diphenhydramine hydrochloride, and haloperidol gel topically over 2 minutes.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Virginia Commonwealth University/Massey Cancer Center

Richmond, United StatesOpen Virginia Commonwealth University/Massey Cancer Center in Google Maps
CompletedOne Study Center