Completed

AsynchronyPrevalence of Patient Ventilator Asynchrony in Trauma and Surgical Patients

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What is being collected

Data Collection

Collected from today forward - Prospective
Who is being recruted

Patient-Ventilator Asynchrony+6

+ Respiration Disorders

+ Respiratory Insufficiency

Over 18 Years
+4 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Ecologic or Community

Assessing exposures and health outcomes at the community level in order to identify population-wide health trends.
Observational
Study Start: July 2009
See protocol details

Summary

Principal SponsorUniversity of Cincinnati
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: July 1, 2009

Actual date on which the first participant was enrolled.

This is a prospective observational study to determine the prevalence of patient/ventilator asynchrony in a cohort of trauma and surgical patients. There will be two 20-minute periods of observation. The first will be during the first 24 hours of mechanical ventilation and the second will take place when the patient is being weaned from the ventilator and is triggering half or more of all ventilator breaths. The study team will use computer-captured waveforms to determine the proportion of all breaths that are asynchronous. This proportion is the primary outcome variable of the study. The study hypothesis is that the proportion of asynchronous breaths is higher in patients with higher levels of sedation, as measured by the Richmond Agitation-Sedation Scale (RASS) and the Confusion Assessment Methods for the Intensive Care Unit (CAM-ICU). This hypothesis will be tested using repeated measures analysis of variance.

Official TitlePrevalence of Patient Ventilator Asynchrony in Trauma and Surgical Patients
NCT01049958
Principal SponsorUniversity of Cincinnati
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

36 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Ecologic or Community

These studies look at groups or populations rather than individuals. They explore community-wide exposures and health outcomes to understand public health trends and risks at a broader scale.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Patient-Ventilator AsynchronyRespiration DisordersRespiratory InsufficiencyRespiratory Tract DiseasesSigns and SymptomsSigns and Symptoms, RespiratoryPathological Conditions, Signs and SymptomsWounds and InjuriesWounds, Nonpenetrating

Criteria

2 inclusion criteria required to participate
Trauma or surgical diagnosis

Patients requiring mechanical ventilation

2 exclusion criteria prevent from participating
Patients with no spontaneous breathing efforts due to injury or chemical paralysis

Patients with leaks in the patient ventilator system precluding evaluation of waveforms

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Study Objectives

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

University Hospital

Cincinnati, United StatesOpen University Hospital in Google Maps
CompletedOne Study Center