Suspended

A Study of the Effect of ARC1779 Injection on Cerebral Microembolism in Patients Undergoing Carotid Endarterectomy

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What is being tested

ARC1779 Injection

+ Placebo (normal saline)

Drug
Who is being recruted

Arterial Occlusive Diseases+10

+ Brain Diseases

+ Cardiovascular Diseases

From 18 to 80 Years
+19 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Placebo-ControlledPhase 2
Interventional
Study Start: February 2009
See protocol details

Summary

Principal SponsorArchemix Corp.
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: February 1, 2009

Actual date on which the first participant was enrolled.

The purpose of this study is to determine, in patients undergoing carotid endarterectomy, the effect of ARC1779 Injection on the number of microembolic signals detected by transcranial Doppler immediately after surgery. This study will also evaluate the safety of ARC1779 Injection with respect to bleeding risk in patients in the peri-operative (during surgery) period.

Official TitleA Study of the Effect of ARC1779 Injection on Cerebral Microembolism in Patients Undergoing Carotid Endarterectomy
NCT00742612
Principal SponsorArchemix Corp.
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

100 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 80 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Arterial Occlusive DiseasesBrain DiseasesCardiovascular DiseasesCarotid Artery DiseasesCentral Nervous System DiseasesIntracranial Embolism and ThrombosisCerebrovascular DisordersNervous System DiseasesThromboembolismVascular DiseasesEmbolism and ThrombosisCarotid StenosisIntracranial Embolism

Criteria

7 inclusion criteria required to participate
Male or female patients;
/= 18 to </= 80 years of age;
Planned carotid endarterectomy;
Carotid stenosis (either symptomatic or asymptomatic);
Show More Criteria
12 exclusion criteria prevent from participating
Trauma or surgery within preceding 30 days;
Lack of acoustic window allowing TCD recordings;
Unable or unwilling to consent;
Metallic prosthetic cardiac valve;
Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

50% chance of being blinded to the placebo group

Treatment Groups

Group I

Active Comparator
ARC1779 Injection

Group II

Placebo
Placebo (normal saline)

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 7 locations

Suspended

Hackensack University Medical Center

Hackensack, United StatesOpen Hackensack University Medical Center in Google Maps
Suspended

Eddy Scurlock Stroke Center - Methodist Hospital

Houston, United States
Suspended

Addenbrooke's Hospital, Department of Vascular Surgery

Cambridge, United Kingdom
Suspended

University Hospitals Coventry and Warwickshire NHS TRUST

Coventry, United Kingdom
Suspended7 Study Centers