Suspended
OPOZAHNEvaluation of the Influence of Alendronate on Wound Healing After Dental Implants in Patients With Osteoporosis
What is being tested
alendronate once weekly 70mg
+ placebo
Drug
Who is being recruted
Bone Diseases+3
+ Bone Diseases, Metabolic
+ Metabolic Diseases
From 60 to 75 Years
+10 Eligibility Criteria
How is the trial designed
Treatment Study
Placebo-ControlledPhase 4
Interventional
Study Start: January 2004
Summary
Principal SponsorCharite University, Berlin, Germany
Study ContactDieter Felsenberg, Prof. Dr.More contacts
Last updated: January 27, 2026Sourced from a government-validated database.Claim as a partner
Study start date: January 1, 2004
Actual date on which the first participant was enrolled.The purpose of this study is to evaluate the influence of alendronate therapy on the wound healing after dental implants in patients with osteoporosis.
Official TitleEvaluation of the Influence of Alendronate on Wound Healing After Dental Implants in Patients With Osteoporosis
Principal SponsorCharite University, Berlin, Germany
Study ContactDieter Felsenberg, Prof. Dr.More contacts
Last updated: January 27, 2026Sourced from a government-validated database.Claim as a partner
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.Design Details
45 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Treatment Study
These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Conditions
Criteria
Female
Biological sex of participants that are eligible to enroll.From 60 to 75 Years
Range of ages for which participants are eligible to join.Healthy volunteers allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Bone DiseasesBone Diseases, MetabolicMetabolic DiseasesMusculoskeletal DiseasesNutritional and Metabolic DiseasesOsteoporosis
Criteria
4 inclusion criteria required to participate
Postmenopausal women > 2 years after menopause
Age between 60 and 75 years
Possibility to insert a dental implant
Osteoporosis as defined by WHO criteria (intervention group), or women without osteoporosis / osteopenia (non-intervention group)
6 exclusion criteria prevent from participating
Pathological findings in the jaw bone
Chronic inflammatory rheumatoid disease
Bisphosphonate treatments during the last 12 months
Inflammatory or metabolic bone disease, excluding osteoporosis
Show More Criteria
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.Treatment Groups
Study Objectives
2 intervention groups are designated in this study
50% chance of being blinded to the placebo group
Treatment Groups
Group I
Active Comparatoralendronate once weekly 70mg, calcium 1000mg and Vitamin D 800 IU daily, dental implant
Group II
Placeboplacebo once weekly, calcium 1000mg and Vitamin D 800 IU daily; dental implant
Study Objectives
Primary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location
Recruiting
Centre for Muscle and Bone Research, Charité - Campus Benjamin Franklin
Berlin, GermanyOpen Centre for Muscle and Bone Research, Charité - Campus Benjamin Franklin in Google MapsSuspendedOne Study Center