Suspended
Comparison of the Efficacy of Topical Ibuprofen to Oral Ibuprofen in Adolescent Athletes
What is being tested
Ibuprofen
+ ibuprofen
Drug
Who is being recruted
Wounds and Injuries
+ Soft Tissue Injuries
From 12 to 19 Years
+13 Eligibility Criteria
How is the trial designed
Treatment Study
Interventional
Study Start: May 2006
Summary
Principal SponsorAkron Children's Hospital
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner
Study start date: May 1, 2006
Actual date on which the first participant was enrolled.This study was made to compare the efficacy of topical ibuprofen in gel form with oral ibuprofen in the treatment of sub-acute soft tissue injuries while comparing the tolerability of the delivery methods
Official TitleComparison of the Efficacy of Topical Ibuprofen to Oral Ibuprofen in Adolescent Athletes
Principal SponsorAkron Children's Hospital
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.Design Details
60 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Treatment Study
These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Conditions
Criteria
Any sex
Biological sex of participants that are eligible to enroll.From 12 to 19 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Wounds and InjuriesSoft Tissue Injuries
Criteria
2 inclusion criteria required to participate
Age 12-19yo
soft tissue injury or flare up of soft tissue injury within 10 days to 8 weeks
11 exclusion criteria prevent from participating
opioid use within 7 days
Known hypersensitivity to aspirin or any NSAID,
allergy to eggs or egg products
history of asthma, renal disease, GI disease, active or suspected bleeding peptic ulcer (past or present), anemia, hypertension, other systemic disease significantly affecting liver or renal function
Show More Criteria
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.Treatment Groups
Study Objectives
2 intervention groups are designated in this study
This study does not include a placebo group
Treatment Groups
Group I
Placebo ibuprofen liposomal transdermal gel with active ibuprofen capsules
Group II
Active ibuprofen liposomal transdermal gel with placebo ibuprofen capsule
Study Objectives
Primary Objectives
Secondary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location
Suspended
Sports Medicine Department at Akron Children's Hospital
Akron, United StatesOpen Sports Medicine Department at Akron Children's Hospital in Google MapsSuspendedOne Study Center