Completed

The Effects of Knee Malalignment and Quadriceps Strengthening on the Adduction Moment in Individuals With Medial Knee Osteoarthritis

0 criteria met from your profileSee at a glance how your profile meets each eligibility criteria.
What is being tested

Data Collection

Who is being recruted

Arthritis+3

+ Joint Diseases

+ Musculoskeletal Diseases

Over 50 Years
+12 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Phase 2 & 3
Interventional
Study Start: May 2004
See protocol details

Summary

Principal SponsorUniversity of Melbourne
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: May 1, 2004

Actual date on which the first participant was enrolled.

Although quadriceps strengthening is the cornerstone of physiotherapy management, recent evidence suggests that high quadriceps strength in patients with malaligned knees may increase OA progression. This study investigates the effects of quadriceps strengthening on the adduction moment in patients with medial knee OA with and without malalignment. 107 participants with and without varus knee malalignment were recruited and randomised into an exercise or a control group. Participants in the exercise group were taught five quadriceps strengthening exercises by a project physiotherapist to be performed five days a week for twelve weeks at home. The exercises were: 1. Quadriceps exercise over fulcrum using ankle weight 2. Straight leg raise exercise using ankle weight 3. Long arc knee extension exercise in sitting using ankle weight 4. Knee extension exercise with isometric hold at 60° knee flexion using ankle weight 5. Knee extension exercise with isometric hold at 60° knee flexion using an elastic band. Each exercise was performed at 2x10 repetitions for the first 2 weeks and 3x10 repetitions thereafter. Participants visited the physiotherapist 7 times at Week 1, 2, 3, 4, 5, 7 and 10. They were given the ankle weights and elastic band to bring home and instructed about the repetitions and weights to use by the physiotherapist, who also checked and progressed their exercises. The average duration of the physiotherapy sessions was 30 minutes. To monitor compliance, each participant was given an exercise instructions sheet and kept a training diary to record the exercises they had done. The control group received no intervention.

Official TitleThe Effects of Knee Malalignment and Quadriceps Strengthening on the Adduction Moment in Individuals With Medial Knee Osteoarthritis
Principal SponsorUniversity of Melbourne
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

107 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.


Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 50 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

ArthritisJoint DiseasesMusculoskeletal DiseasesOsteoarthritisRheumatic DiseasesOsteoarthritis, Knee

Criteria

5 inclusion criteria required to participate
Medial joint space narrowing greater than lateral joint space narrowing on x-ray

Pain in the knee

Osteophytes on knee x-ray

Self-reported pain on the inner aspect of the study knee

Show More Criteria

7 exclusion criteria prevent from participating
Knee surgery within the previous 6 months

History of lower limb joint replacements

Systemic arthritic conditions such as rheumatic or psoriatic arthritis

Valgus knee deformity (> 5º)

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Study Objectives

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

The University of Melbourne

Melbourne, AustraliaOpen The University of Melbourne in Google Maps
CompletedOne Study Center