Suspended
Randomized Study Comparing Ligation With Propranolol for Primary Prophylaxis of Variceal Bleeding in Candidates for Liver Transplantation
What is being tested
Data Collection
Who is being recruted
Digestive System Diseases+7
+ Esophageal and Gastric Varices
+ Esophageal Diseases
From 18 to 65 Years
+17 Eligibility Criteria
How is the trial designed
Prevention Study
Phase 3
Interventional
Summary
Principal SponsorUniversity of Padova
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner
Whether beta-blockers or banding is the best therapy for primary prophylaxis of variceal bleeding is subject to debate. A randomized comparison between the two treatments was performed in candidates for liver transplantation. Patients with Child B and C cirrhosis with high risk varices and no previous variceal bleeding are randomized to propranolol or variceal bleeding. Primary end point is variceal bleeding
Official TitleRandomized Study Comparing Ligation With Propranolol for Primary Prophylaxis of Variceal Bleeding in Candidates for Liver Transplantation
Principal SponsorUniversity of Padova
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.Design Details
120 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Prevention Study
Prevention studies aim to stop a disease from developing. They often involve people at risk and test things like vaccines, lifestyle changes, or preventive medications.
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Conditions
Criteria
Any sex
Biological sex of participants that are eligible to enroll.From 18 to 65 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Digestive System DiseasesEsophageal and Gastric VaricesEsophageal DiseasesFibrosisGastrointestinal DiseasesHypertension, PortalLiver CirrhosisLiver DiseasesPathologic ProcessesPathological Conditions, Signs and Symptoms
Criteria
6 inclusion criteria required to participate
liver cirrhosis
child pugh>=B7
studied for transplantation
age between 18 an 65 ys
Show More Criteria
11 exclusion criteria prevent from participating
non cooperation
esophageal varices less than F2 blue
gastric varices
previous variceal surgical or radiological or endoscopical treatment
Show More Criteria
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.Study Objectives
Study Objectives
Primary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location
Suspended
Clinica Chirurgica 1^, Policlinico Universitario, Via Giustiniani 2
Padua, ItalyOpen Clinica Chirurgica 1^, Policlinico Universitario, Via Giustiniani 2 in Google MapsSuspendedOne Study Center