Recruiting

CKiDRisk Factors and Impact Analysis for Chronic Kidney Disease in Children

Study Aim

This study aims to observe and understand the risk factors and impacts of chronic kidney disease in children, with a focus on determining the time it takes for a child to require Kidney Replacement Therapy.

What is being collected

Data Collection

Collected from today forward - Prospective

DNA Samples

Who is being recruted

Urogenital Diseases+9

+ Chronic Disease

+ Female Urogenital Diseases and Pregnancy Complications

From 6 Months to 22 Years

+15 Eligibility Criteria

See all eligibility criteria

How is the trial designed

Cohort

Tracking disease incidence in order to identify risk factors and understand disease progression over time.

Observational

Study Start: October 2003

See protocol details

Summary

Principal SponsorJohns Hopkins Bloomberg School of Public Health

Study ContactSusan Furth, MD, PhDMore contacts

Last updated: January 28, 2026

Sourced from a government-validated database.Claim as a partner

Study start date: October 1, 2003

Actual date on which the first participant was enrolled.

The Chronic Kidney Disease in Children Prospective Cohort Study (CKiD) is an ongoing research initiative that started in 2003. Its primary aim is to understand the factors that lead to a decline in kidney function in children with chronic kidney disease (CKD). The study also seeks to uncover how this decline affects various aspects of health, such as the risk of heart disease, cognitive function, behavior, and growth. Recently, the study's goals have expanded to examine the impact of childhood CKD on social function, emotional well-being, and the transition to adult nephrology care. In this observational study, participants report their health status and experiences over time. The main outcome measured is the time it takes for a child with CKD to need Kidney Replacement Therapy (KRT). This is calculated from the date of diagnosis to the date when KRT becomes necessary. Participants self-report the exact KRT date, which is then verified through medical records.

Official TitleChronic Kidney Disease in Children Prospective Cohort Study (CKiD)

NCT00327860

Principal SponsorJohns Hopkins Bloomberg School of Public Health

Study ContactSusan Furth, MD, PhDMore contacts

Last updated: January 28, 2026

Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Design Details

1300 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Cohort

These studies follow a group of individuals with common characteristics (such as a condition or birth year) over a specific period to study health outcomes or exposures.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.

Conditions

Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 6 Months to 22 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Urogenital DiseasesChronic DiseaseFemale Urogenital Diseases and Pregnancy ComplicationsKidney DiseasesPathologic ProcessesPathological Conditions, Signs and SymptomsUrologic DiseasesDisease AttributesRenal Insufficiency, ChronicRenal InsufficiencyFemale Urogenital DiseasesMale Urogenital Diseases

Criteria

4 inclusion criteria required to participate

Age between 1 and 16 years (before 17th birthday) for Cohorts 1 and 2; age between 6 months and 16 years (before 17th birthday) for Cohort 3; age between 16 to 22 years (before 23rd birthday) for Cohort 4 and regularly seen by pediatric nephrologist prior to enrollment

Estimated (based on SCr) Schwartz GFR between 30 and 90 ml/min|1.73m2 for Cohort 1 OR an estimated GFR between 45 and 90 ml/min|1.73m2 based on the updated Schwartz formula for Cohort 2; an estimated GFR ≤60 based on the CKiD Under 25 estimating equation (U25eGFR) OR KRT experience (dialysis or transplant) for Cohort 4

Willingness and ability to provide informed consent and assent

For Cohort 3, children with non-glomerular diagnosis and duration of kidney disease less than 5 years will be enrolled.

11 exclusion criteria prevent from participating

Solid organ (other than kidney), bone marrow or stem cell transplantation

Cancer diagnosis and receiving treatment or within 12 months post completion of treatment

HIV diagnosis and receiving treatment or within 12 months post completion of treatment

Current pregnancy or pregnancy within past twelve months

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 2 locations

Recruiting

Children's Mercy Kansas City

Kansas City, United StatesOpen Children's Mercy Kansas City in Google Maps

Recruiting

The Children's Hospital of Philadelphia

Philadelphia, United States

Recruiting

2 Study Centers