Completed

V3: Vancouver-Victoria Valacyclovir Trial for Early Psychosis

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What is being tested

Data Collection

Who is being recruted

Bipolar and Related Disorders+4

+ Mental Disorders

+ Bipolar Disorder

From 18 to 65 Years
+9 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Phase 2
Interventional
Study Start: September 2005
See protocol details

Summary

Principal SponsorUniversity of British Columbia
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: September 1, 2005

Actual date on which the first participant was enrolled.

There is evidence that some of the symptoms of psychosis may be related to past infection with common viruses. Researchers are looking to recruit a total of 100 subjects with evidence in the past, of exposure to at least 1 of 3 viruses. The viruses include herpes type 1 (HSV-1, which causes cold sores of the lip and has affected about 6/10 people in Vancouver), herpes type 2 (HSV-2 which causes genital sores, and has affected less than 1/10 people in Vancouver) and cytomegalovirus (CMV, which causes few symptoms but has affected 8/10 people in Vancouver). People who have been infected with these viruses in the past develop antibodies in the blood. The antibodies can be measured in blood, and are a test of whether or not there was infection in the past, and possibly affecting the symptoms of psychosis.

Official TitleV3: Vancouver-Victoria Valacyclovir Trial for Early Psychosis
NCT00175513
Principal SponsorUniversity of British Columbia
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

100 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 65 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Bipolar and Related DisordersMental DisordersBipolar DisorderPsychotic DisordersSchizophreniaMood DisordersSchizophrenia Spectrum and Other Psychotic Disorders

Criteria

4 inclusion criteria required to participate
Subjects antipsychotic, mood stabilizing and antidepressant drug treatment must have been stable for at least 3 months, and there is no plan to change the drug treatment during the 4-month phase of the study.
Subjects must be seropositive for HSV-1, HSV-2 and/or CMV.
Subjects must achieve a level of understanding and expressive capacity sufficient to communicate adequately with the study coordinator and to participate in cognitive testing.
Subjects must be able to provide written informed consent.
5 exclusion criteria prevent from participating
Females of childbearing age will agree not to become pregnant and will agree to use a medically acceptable method of birth control.
Inability to participate in cognitive testing due to severe persistent psychosis or other condition.
Mental handicap.
Subjects with known hypersensitivity or allergy to valacyclovir or acyclovir.
Show More Criteria

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 2 locations

Suspended

Eric Martin Pavilion

Victoria, CanadaOpen Eric Martin Pavilion in Google Maps
Suspended

Peace Arch Hospital

White Rock, Canada
Completed2 Study Centers