Completed

Health-Related Outcomes For Hodgkin's Disease Survivors

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What is being collected

Data Collection

Collected from today forward - Prospective
Who is being recruted

Hemic and Lymphatic Diseases+5

+ Immune System Diseases

+ Immunoproliferative Disorders

See all eligibility criteria
How is the trial designed

Cohort

Tracking disease incidence in order to identify risk factors and understand disease progression over time.
Observational
Study Start: December 2004
See protocol details

Summary

Principal SponsorChildren's Oncology Group
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: December 1, 2004

Actual date on which the first participant was enrolled.

OBJECTIVES: * Determine the cumulative incidence and characterize the spectrum of selected adverse physiologic and psychosocial outcomes, using self-report and clinical evaluation, in patients previously treated for childhood Hodgkin's lymphoma. * Compare the cumulative incidence and spectrum of self-reported adverse outcomes of these patients, using data collected at a comparable time period after diagnosis, with Hodgkin's lymphoma survivors from the Childhood Cancer Survivor Study (CCSS). * Compare self-reported health-related outcomes with outcomes detected by clinical evaluation and medical record review of each group of patients. OUTLINE: This is a cohort, cross-sectional, multicenter study. * Contemporary group: Patients complete a self-report of long-term outcomes questionnaire and a comprehensive psychosocial questionnaire. A medical record review is then performed. Patients then undergo a comprehensive risk-based clinical evaluation with specific examinations and studies based upon the Children's Oncology Group Late Effects Screening Guidelines and the patients' specific therapeutic exposures. * Childhood Cancer Survivor Study (CCSS) group: Patients undergo a telephone interview and have medical records reviewed to validate select self-reported long-term outcomes. Patient replies from the baseline CCSS questionnaire (which was completed at certain timepoints after diagnosis) are reviewed for targeted long-term outcomes. PROJECTED ACCRUAL: Approximately 1,000 patients will be accrued for this study.

Official TitleHealth-Related Outcomes For Hodgkin's Disease Survivors
NCT00091091
Principal SponsorChildren's Oncology Group
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

530 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Cohort

These studies follow a group of individuals with common characteristics (such as a condition or birth year) over a specific period to study health outcomes or exposures.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Hemic and Lymphatic DiseasesImmune System DiseasesImmunoproliferative DisordersLymphatic DiseasesLymphomaLymphoproliferative DisordersNeoplasmsNeoplasms by Histologic Type

Criteria

DISEASE CHARACTERISTICS: * Contemporary cohort * At least 5 years since diagnosis of Hodgkin's lymphoma * Diagnosed between the years 1987-2001 * 21 and under at diagnosis * No evidence of disease * Prior treatment on 1 of the following protocols during the years 1987-2001: * Children's Cancer Group (CCG) CCG-5942, CCG-59704 * Pediatric Oncology Group (POG) POG-8625, POG-8725, POG-9425, POG-9426 * Pediatric Hodgkin's Consortium: VAMP, VEPA, VAMP/COP * Institutional protocols COPP/ABV, MOPP/ABVD, ABVD * Childhood Cancer Survivor Study (CCSS) Hodgkin's lymphoma cohort * Current enrollment in the CCSS * Diagnosed between the years 1976-1986 * Completed baseline questionnaire at comparable timepoints (as the contemporary cohort) after diagnosis PATIENT CHARACTERISTICS: Age * Any age Performance status * Not specified Life expectancy * Not specified Hematopoietic * Not specified Hepatic * Not specified Renal * Not specified PRIOR CONCURRENT THERAPY: Biologic therapy * Not specified Chemotherapy * Not specified Endocrine therapy * Not specified Radiotherapy * Not specified Surgery * Not specified

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Study Objectives

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 15 locations

Suspended

Lucile Packard Children's Hospital at Stanford University Medical Center

Palo Alto, United StatesOpen Lucile Packard Children's Hospital at Stanford University Medical Center in Google Maps
Suspended

Yale Cancer Center

New Haven, United States
Suspended

University of Chicago Cancer Research Center

Chicago, United States
Suspended

Hackensack University Medical Center Cancer Center

Hackensack, United States
Completed15 Study Centers