A Safety Study of Infusion of Ex Vivo Selectively Amplified Unrelated Cord Blood Stem Cells in Subjects With Hematological Malignancies Receiving Unrelated Cord Blood Transplantation
Data Collection
Bone Marrow Diseases+15
+ Chronic Disease
+ Hematologic Diseases
Treatment Study
Summary
Study start date: March 1, 2004
Actual date on which the first participant was enrolled.This study hopes to show that specially treated umbilical cord cells, called stem cells, can be safely given to a person after they receive chemoradiation therapy or chemotherapy for their illness. During chemoradiation therapy or chemotherapy, a person loses all of the cells that are needed to make the different types of cells in their blood, including their immune system cells. These cells must be replaced in order for the blood and immune systems to work properly. Some people receive bone marrow transplants or other types of stem cell transplants to get the cells they need. CB001 is being developed as an option for people who need bone marrow transplants or other types of transplants to replace those cells. It is also being developed for people who do not have the option of other types of transplants.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.10 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Treatment Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.From 12 to 60 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Inclusion Criteria: * Do not have identical or 5/6 related matched bone marrow, peripheral blood or umbilical cord * Stable disease and lack of unrelated donor * Acute myeloid leukemia (AML) in 2nd or subsequent complete remission or first remission with high risk features * ALL in 2nd or subsequent remission or first remission with high risk features * Myelodysplastic syndrome (MDS) * Non-Hodgkin Lymphoma (NHL) * Chronic Myelogenous Leukemia (CML) * Adequate function of heart, liver, kidneys and lungs Exclusion Criteria: * Females who are pregnant * Poor ability to perform daily activities * Weight under 40 kilograms (88 pounds) * AML caused by chemoradiation * Prior stem cell transplant * Uncontrolled infection at time of transplant * Active fungal infection * HIV infection * Primary myelofibrosis * Receiving other research drugs * Unable to provide informed consent
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 4 locations
Indiana University Cancer Center
Indianapolis, United StatesHackensack University Medical Center
Hackensack, United StatesRoswell Park Cancer Institute
Buffalo, United States