Completed

ACRIN6664The National CT Colonography Trial: Multicenter Assessment of Accuracy for Detection of Large Adenomas and Cancers in a Healthy Screening Population

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What is being tested

CT Colonography

Procedure
Who is being recruted

Colonic Diseases+8

+ Digestive System Diseases

+ Digestive System Neoplasms

Over 50 Years
See all eligibility criteria
How is the trial designed

Screening Study

Interventional
Study Start: February 2005
See protocol details

Summary

Principal SponsorAmerican College of Radiology Imaging Network
Last updated: January 18, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: February 1, 2005

Actual date on which the first participant was enrolled.

OBJECTIVES: Primary * Compare the sensitivity of computed tomographic colonography (CTC) vs colonoscopy for detecting significantly large lesions (≥ 10 mm in diameter) in asymptomatic participants, in terms of specificity, area under the ROC curve, and predictive values for detecting clinically significant colorectal neoplasia. Secondary * Determine the interobserver variation in accuracy of interpreting CTC examinations of these participants, including any benefits of a primary 3-dimensional read and/or independent second interpretations. * Determine the effects of different colon preparations on the accuracy of CTC in these participants. * Compare participant acceptance and willingness to have a repeat examination by CTC vs colonoscopy. * Determine the accuracy of CTC in detecting flat lesions in the colon of these participants. OUTLINE: This is a multicenter study. Participants receive an oral laxative, oral bisacodyl, and three doses of oral barium sulphate 24 hours before imaging. After cathartic cleansing, participants undergo computed tomographic colonography followed by colonoscopy. Participants are followed up for approximately 4 weeks. PROJECTED ACCRUAL: A total of 2,607 participants will be accrued for this study.

Official TitleThe National CT Colonography Trial: Multicenter Assessment of Accuracy for Detection of Large Adenomas and Cancers in a Healthy Screening Population 
NCT00084929
Principal SponsorAmerican College of Radiology Imaging Network
Last updated: January 18, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

2600 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Screening Study

Screening studies test new methods to find diseases or risk factors early—before any symptoms appear. This helps catch health issues sooner, when they may be easier to treat.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 50 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Colonic DiseasesDigestive System DiseasesDigestive System NeoplasmsGastrointestinal DiseasesGastrointestinal NeoplasmsIntestinal DiseasesIntestinal NeoplasmsNeoplasmsNeoplasms by SiteRectal DiseasesColorectal Neoplasms

Criteria

1. Inclusion Criteria * Male or female outpatients * Aged 50 years or older * Scheduled for screening colonoscopy * Participant's signed informed consent 2. Exclusion Criteria * Symptoms of disease of the lower gastrointestinal tract, including * Melanotic stools or/and hematochezia on more than one occasion in the previous six months * Lower abdominal pain that would normally require a medical evaluation * Inflammatory bowel disease and/or familial polyposis syndrome * Serious medical conditions that would increase the risk associated with colonoscopy or are so severe that screening would have no benefit * Pregnancy * Previous colonoscopy within the past five years * Anemia (hemoglobin less than 10 gm/dl) * Positive fecal occult blood test (FOBT)

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
CT colonography conducted during the same assessment as colonoscopy.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 14 locations

Suspended

Mayo Clinic Scottsdale

Scottsdale, United StatesSee the location
Suspended

Moores UCSD Cancer Center

La Jolla, United States
Suspended

Jonsson Comprehensive Cancer Center at UCLA

Los Angeles, United States
Suspended

Veterans Affairs Medical Center - San Francisco

San Francisco, United States
Completed14 Study Centers