PET Imaging of Monoamine Transporters in OCD-related Disorders
Data Collection
Anxiety Disorders
+ Mental Disorders
+ Obsessive-Compulsive Disorder
Summary
Study start date: May 10, 2004
Actual date on which the first participant was enrolled.Evidence suggests that the symptoms of obsessive-compulsive disorder (OCD) arise from dysfunction of both the serotonergic and dopaminergic neurotransmitter systems. These two neurotransmitter systems are presumed to play a key modulatory role at the limbic-motor interface of the fronto-subcortical circuitry. However, in vivo knowledge linking the serotonergic and dopaminergic systems to OCD and OCD-related disorders is limited. In the current protocol, we plan to use PET to image the serotonin transporter (SERT) within the new radioligand \[11C\]DASB, in order to delineate regional abnormalities in SERT binding in drug-naive or drug-free OCD patients in comparison to healthy volunteers. In addition, we plan to examine the relationship between the regional PET measures of SERT and clinical severity measures of OCD. The goal of the present study is, thus, to further our understanding of the role of the serotonergic system in the pathophysiology of OCD.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.30 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.From 18 to 65 Years
Range of ages for which participants are eligible to join.Healthy volunteers allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
* INCLUSION CRITERIA: Patients and Controls: Age: 18-65. Patients- DSM-IV criteria for OCD. Controls- not required Patients and Controls: Good health, with absence of serious medical illnesses, such as congestive heart failure, diabetes, kidney failure, epilepsy or cancer. EXCLUSION CRITERIA: Healthy Subjects: History or current DSM-IV Axis I diagnostic criteria. Patients and Controls: Current diagnosis of major depressive disorder. Patients and Controls: Psychotropic medications, including SSRIs and antipsychotic medications. Drug free period must be greater than 4 weeks. Patients and Controls: Claustrophobia Patients and Controls: Pregnancy. Women with child bearing potential. Patients and Controls: Prior participation in other research protocols within the past year such that a radiation exposure together with the present study would exceed the annual limits. Patients and Controls: Any condition that increases risk for MRI (e.g., pacemaker, metallic foreign body in the eye, etc.)
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, United StatesOpen National Institutes of Health Clinical Center, 9000 Rockville Pike in Google Maps