Family Studies of the Genetics of Ankylosing Spondylitis
Data Collection
Axial Spondyloarthritis+10
+ Ankylosis
+ Arthritis
Summary
Study start date: September 1, 1999
Actual date on which the first participant was enrolled.AS is a chronic inflammatory disease that eventually causes the affected vertebrae to fuse or grow together. The cause of AS is unknown, but genetic factors seem to play a role. Risk factors include a family history of ankylosing spondylitis and male gender. This study will collect patient information and blood samples from affected patients (and when available, both parents of the affected patients) of 400 families with children fulfillling the modified New York criteria for AS. Diagnosis of AS will be verified by patient questionnaire, medical record review, and pelvic radiographs. Information from these patients will be used to search the human genome for disease-associated loci and/or genes. This study will also utilize contributions of investigators who have conducted recent clinical or genetic research in AS at 10 academic medical centers throughout North America (the North American Spondylitis Consortium, or NASC).
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.1600 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.Healthy volunteers allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Inclusion Criteria: * Meet modified New York criteria for ankylosing spondylitis (AS) * AS as confirmed by X-rays of sacroiliac joints (between the pelvis and spine) * At least two siblings in family with AS * Parents of the participants with AS have the option of also being enrolled
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 2 locations
University of Texas - Health Science Center at Houston
Houston, United States