Completed

Gender, Obesity, C-Reactive Protein, and Oxidative Stress

0 criteria met from your profileSee at a glance how your profile meets each eligibility criteria.
What is being tested

Vitamin C

+ Vitamin E

+ Placebo

Dietary Supplement
Who is being recruted

Cardiovascular Diseases

Over 18 Years
See all eligibility criteria
How is the trial designed

Prevention Study

Placebo-Controlled
Interventional
Study Start: April 2004
See protocol details

Summary

Principal SponsorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Last updated: January 13, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: April 1, 2004

Actual date on which the first participant was enrolled.

Participants will be given 1000 mg vitamin C or 800 IU vitamin E daily for 60 days.

Official TitleGender, Obesity, C-Reactive Protein, and Oxidative Stress 
NCT00079963
Principal SponsorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Last updated: January 13, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

396 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Prevention Study

Prevention studies aim to stop a disease from developing. They often involve people at risk and test things like vaccines, lifestyle changes, or preventive medications.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Cardiovascular Diseases

Criteria

Inclusion criteria: * Nonsmoker and not passively exposed * Males and females 18 year and older * Able to take vitamin supplements * Able to take acetominophen instead of aspirin or NSAIDs during the study Exclusion criteria: * Pregnancy or lactation * History of ever smoking or passive smoke exposure in the last year * Active liver disease; history of HIV/AIDS, diabetes, kidney stones, hemochromatosis, or autoimmune diseases; heart disease, stroke, or cancer in the last 5 years * User of prescribed anti-inflammatory or lipid-lowering medications, oral contraceptives, hormone replacement therapy, or blood-thinning drugs * User of iron supplements or vitamin E at 600 IU per day or more * Consumption of more than 2 alcoholic beverages per day

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

3 intervention groups are designated in this study

33.333% chance of being blinded to the placebo group

Treatment Groups

Group I

Experimental
Vitamin C

Group II

Experimental
Vitamin E

Group III

Placebo
Placebo

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

University of California, Berkeley School of Public Health

Berkeley, United StatesSee the location
CompletedOne Study Center