A Phase I Study Of Continuous Infusion EMD 121974 In Patients With Solid Tumors
cilengitide
Plasmablastic Lymphoma+46
+ Lymphadenopathy
+ Bacterial Infections and Mycoses
Treatment Study
Summary
Study start date: December 1, 2003
Actual date on which the first participant was enrolled.PRIMARY OBJECTIVES: I. Determine the dose-limiting toxicity, maximum feasible dose, and recommended phase II dose of cilengitide (EMD 121974) in patients with advanced solid tumors or lymphoma. II. Determine the safety and tolerability of this drug in these patients. SECONDARY OBJECTIVES: I. Determine the pharmacokinetics of this drug in these patients. II. Determine the antineoplastic activity of this drug in these patients. OUTLINE: This is a dose-escalation study. Patients receive cilengitide (EMD 121974) IV continuously on weeks 1-4. Courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity. Cohorts of 3-6 patients receive escalating doses of EMD 121974 until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.45 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Treatment Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.Over 18 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Inclusion Criteria: * Histologically confirmed solid tumor or lymphoma * Refractory to standard therapy or no standard therapy exists * Measurable or evaluable disease * No active brain metastases * Previously treated brain metastases allowed provided the patient is not currently receiving corticosteroids * Primary brain neoplasms allowed, regardless of corticosteroid use * Performance status - Karnofsky 70-100% * WBC ≥ 3,000/mm\^3 * Absolute neutrophil count ≥ 1,500/mm\^3 * Platelet count ≥ 100,000/mm\^3 * No life-threatening bleeding diathesis within the past 6 months * Bilirubin normal (unless due to Gilbert's syndrome) * No symptomatic congestive heart failure * No unstable angina pectoris * No cardiac arrhythmia * No prior proven gastric or duodenal ulcer * No clinically significant gastrointestinal blood loss within the past 6 weeks * Not pregnant or nursing * Negative pregnancy test * Fertile patients must use effective contraception * No prior CNS hemorrhage * No psychiatric illness or social situation that would preclude study compliance * No other concurrent uncontrolled illness * No ongoing or active infection * No prior cilengitide (EMD 121974) * No other concurrent biologic therapy * More than 4 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin) and recovered * No concurrent chemotherapy * See Disease Characteristics * More than 4 weeks since prior radiotherapy and recovered * No concurrent palliative radiotherapy * No other concurrent anticancer agents or therapies intended to treat the malignancy * No other concurrent investigational agents * No concurrent anticoagulation therapy that increases INR or aPTT above the normal range * Line prophylaxis allowed
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.One single intervention group is designated in this study
This study does not include a placebo group
Treatment Groups
Group I
ExperimentalStudy Objectives
Primary Objectives
Secondary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location