Prevention of Depression in At-Risk Adolescents
Cognitive-behavioral prevention program
+ Usual care
Mental Disorders+2
+ Behavioral Symptoms
+ Depression
Prevention Study
Summary
Study start date: March 1, 2003
Actual date on which the first participant was enrolled.Depression is a prevalent, chronic, and impairing condition that is often undetected and becomes more difficult to treat as chronicity increases. There is an increasing need to conduct large-scale depression prevention studies in adolescents. This study evaluates a cognitive-behavioral prevention (CBP) program to determine its effectiveness in preventing depressive disorders in at-risk adolescents. The study also will ascertain the costs this intervention to inform attempts at future dissemination of the program in "real world" settings. Participants in this study are randomly assigned to receive either CBP for eight weekly and 6 monthly continuation sessions or usual care. Depressive symptoms and disorders, levels of functioning, and medical and mental health care utilization are assessed at baseline and again at 2, 8, 20, and 32 months after intake.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.316 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Prevention Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.From 13 to 17 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Inclusion Criteria: * A parent has had a depressive disorder during child's life * Adolescent has had a past depressive episode or has current subsyndromal depressive symptoms measured on the Center for Epidemiological Studies Depression Scale (CES-D) Exclusion Criteria: * adolescent or parent ever diagnosed with bipolar I or schizophrenia; * adolescent has a current DSM-IV mood disorder diagnosis
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.2 intervention groups are designated in this study
This study does not include a placebo group
Treatment Groups
Group I
ExperimentalGroup II
Active ComparatorStudy Objectives
Primary Objectives
Secondary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 4 locations
Kaiser Permanente Center for Health Research
Portland, United StatesUniversity of Pittsburgh Medical Center
Pittsburgh, United StatesVanderbilt University
Nashville, United States