Suspended

72-Hour CP-101,606 Infusion for Acute Ischemic Stroke Safety and Efficacy

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What is being tested

Data Collection

Who is being recruted

Brain Diseases+4

+ Cardiovascular Diseases

+ Central Nervous System Diseases

From 40 to 90 Years
+6 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Phase 2
Interventional
Study Start: September 2003
See protocol details

Summary

Principal SponsorPfizer
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: September 1, 2003

Actual date on which the first participant was enrolled.

This study focuses on a new research medication, CP-101,606, and its potential to safely and effectively treat acute ischemic stroke. An acute ischemic stroke occurs when blood flow to a part of the brain is blocked, usually by a blood clot. The study aims to help individuals who have experienced a stroke within the last 6 hours. By exploring this new treatment option, the study hopes to address the urgent need for effective stroke treatments that can minimize brain damage and improve recovery. During the study, participants receive either the research medication, CP-101,606, or a placebo through a 72-hour infusion. Neither the participants nor the researchers know who receives the medication or the placebo, ensuring unbiased results. The study's primary goals are to evaluate if the medication leads to marked neurological improvements and results in no or minimal neurological deficits by the end of the treatment period. These outcomes will help determine the potential benefits and risks associated with CP-101,606 for acute ischemic stroke treatment.

Official TitleA Double-Blind, Placebo-Controlled, Multi-Center Study to Evaluate the Efficacy and Safety of a 72-Hour Infusion of CP-101,606 in Subjects With Acute Ischemic Stroke.
NCT00073476
Principal SponsorPfizer
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

300 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.


Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 40 to 90 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Brain DiseasesCardiovascular DiseasesCentral Nervous System DiseasesCerebrovascular DisordersNervous System DiseasesVascular DiseasesStroke

Criteria

4 inclusion criteria required to participate
Males & females age 40-90 years

Enrolled in study within 6 hours of onset of stroke symptoms

Willing to sign informed consent form

No significant disabilities prior to stroke

2 exclusion criteria prevent from participating
Treatment with t-PA (tissue plasminogen activator)

Premorbid modified rankin scale score of 2 or more

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Study Objectives

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 29 locations

Suspended

Pfizer Investigational Site

La Mesa, United StatesOpen Pfizer Investigational Site in Google Maps
Suspended

Pfizer Investigational Site

Atlanta, United States
Suspended

Pfizer Investigational Site

Fort Wayne, United States
Suspended

Pfizer Investigational Site

Fort Wayne, United States
Suspended29 Study Centers