Assessment of Insulin Resistance and Secretory Capacity for Type 2 Diabetes Prevention in High-Risk Population
This study aims to assess your insulin resistance and secretory capacity, with the goal of preventing Type 2 Diabetes, if you are identified as a high-risk individual.
Data Collection
Diabetes Mellitus+4
+ Diabetes Mellitus, Type 2
+ Endocrine System Diseases
Prevention Study
Summary
This is a pilot study to examine the prevalence of metabolic risk factors (impaired insulin release and impaired insulin sensitivity) for type 2 diabetes mellitus in children and adults from a population that is at high risk for this disease. We hypothesize that at least one of these pre-diabetic traits will be evident in a large proportion of relatives of known type 2 diabetic children as compared to a control group of subjects without a family history of type 2 diabetes. By isolating these traits, it will be possible to determine the relative contributions of genes and environment to each trait and to identify those at risk for subsequent development of type 2 diabetes by virtue of having one trait. Ultimately, those individuals at risk, especially those with impaired insulin release, would hopefully benefit from intervention to prevent the weight gain that will 'unmask' their underlying pancreatic dysfunction and thus prevent or retard the development of type 2 diabetes.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.Prevention Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.From 10 to 20 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Ascertainment criteria for probands: * age 10-20 years and * obesity (BMI \>85% for sex and age) * diabetic criteria as described above or family history (first or second degree relative) with type 2 diabetes
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 2 locations
Russ Berrie Pavilion
New York, United States