Completed

The Effects of Overfeeding on Obesity-Prone (OP) and Obesity-Resistant (OR) Women

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What is being collected

Data Collection

Collected from today forward - Prospective
DNA Samples
Who is being recruted

Behavior+12

+ Behavior, Animal

+ Body Weight

From 25 to 35 Years
See all eligibility criteria
How is the trial designed

Cohort

Tracking disease incidence in order to identify risk factors and understand disease progression over time.
Observational
Study Start: October 2003
See protocol details

Summary

Principal SponsorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: October 1, 2003

Actual date on which the first participant was enrolled.

This is a longitudinal cohort study of how the responses to a 3 day period of controlled overfeeding relate to subsequent weight gain. We hypothesize that thin individuals are resistant to weight gain because they respond to periods of overfeeding by increasing fat oxidation, reducing food intake, and increasing physical activity relative to those who gain weight over time.

Official TitleThe Effects of Overfeeding on Obesity-Prone (OP) and Obesity-Resistant (OR) Women
NCT00072917
Principal SponsorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

100 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Cohort

These studies follow a group of individuals with common characteristics (such as a condition or birth year) over a specific period to study health outcomes or exposures.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 25 to 35 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

BehaviorBehavior, AnimalBody WeightBody Weight ChangesFeeding BehaviorMotor ActivityNutrition DisordersNutritional and Metabolic DiseasesObesitySigns and SymptomsPathological Conditions, Signs and SymptomsThinnessWeight GainOvernutritionOverweight

Criteria

* Half of the subjects will be women, half will be men, * age 25-35, * a range of BMI's from 19-27, for the 'thin subjects' there should be no 1st degree relatives with a BMI\>30. * Subjects should not engage in planned physical activity more than 3 hrs per week. * For the obesity prone group there should be at least 1 1st degree relative with a BMI\>30.

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

University of Colorado Health Sciences Center

Denver, United StatesOpen University of Colorado Health Sciences Center in Google Maps
CompletedOne Study Center