MRI in Autosomal Dominant Partial Epilepsy With Auditory Features
Data Collection
Brain Diseases+6
+ Central Nervous System Diseases
+ Epilepsy
Summary
Study start date: November 10, 2003
Actual date on which the first participant was enrolled.Objectives: to study potential structural and functional abnormalities in patients with an inherited form of epilepsy. Study Population: Patients with autosomal dominant partial epilepsy with auditory features, a newly described syndrome, asymptomatic family members who are gene carriers, and unaffected family members, and normal volunteers. Design: magnetic resonance imaging, electroencephalography, and magnetoencephalography. Outcome measures: detection of structural lesions; regional activation patterns on fMRI.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.72 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.From 21 to 65 Years
Range of ages for which participants are eligible to join.Healthy volunteers allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
* INCLUSION CRITERIA: Patients and family members in kindreds with ADPEAF evaluated by Dr. Ruth Ottman at CPMC: 14 patients with seizures and the LGl1 mutation. 14 family members with the mutation but no seizures. 14 Non-affected family members, who are not carriers of the LGl1 mutation. 30 normal controls selected at NIH, and screened in the CES outpatient clinic with a physical and neurological examination. EXCLUSION CRITERIA: Subjects unable or unwilling to undergo MRI, EEG, and MEG. Women who are pregnant. Subjects under 18. Subjects with medical conditions other than ADPEAF that may affect brain function. Subjects taking medications or neuroactive substances that may affect brain function. Healthy volunteers must be below the age of 55, to reduce the chance of vascular chnages that could affect MRI.
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 2 locations
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, United StatesOpen National Institutes of Health Clinical Center, 9000 Rockville Pike in Google MapsColumbia University
New York, United States