Completed

Mood and Anxiety Disorders in Families Study

0 criteria met from your profileSee at a glance how your profile meets each eligibility criteria.
Study Aim

This study observes the mood and anxiety disorders in families to gather diagnostic interviews, family history, and clinical evaluations to understand symptoms and impairment.

What is being collected

Data Collection

Collected from past medical records and data - Retrospective
Who is being recruted

Mental Disorders+9

+ Brain Diseases

+ Central Nervous System Diseases

From 7 to 120 Years
+10 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Family-Based

Studying health outcomes within families in order to identify genetic or familial contributions to disease.
Observational
Study Start: May 2004
See protocol details

Summary

Principal SponsorNational Institute of Mental Health (NIMH)
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: May 21, 2004

Actual date on which the first participant was enrolled.

This study aims to explore the link between mood disorders, such as bipolar disorder and major depression, and their genetic and familial patterns. Researchers are particularly interested in how these mood disorders might overlap with anxiety disorders and migraines. The study involves a wide range of participants, including individuals diagnosed with various mood and anxiety disorders, as well as their relatives. Understanding these connections could lead to better diagnosis and treatment options for people affected by these conditions, potentially improving their quality of life by tailoring interventions to more specific subgroups within the mood disorder spectrum. Participants in this study will undergo structured interviews to gather detailed information about their mental health and family history. Researchers will also collect DNA samples to look for genetic links. A subset of participants will keep electronic diaries to track their daily experiences and will measure their light exposure and activity levels. This data will help identify biological markers linked to mood disorders. The study will measure how often these disorders appear within families and will look for symptoms that might be passed down or shared. This ongoing research could reveal important insights into how mood disorders are inherited and how they interact with other health issues.

Official TitleFamily Study of Affective and Anxiety Spectrum Disorders
NCT00071786
Principal SponsorNational Institute of Mental Health (NIMH)
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

1944 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Family-Based

These studies involve members of the same family to explore how genetics and shared environments may contribute to a disease. They help researchers pinpoint inherited risk factors.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 7 to 120 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Mental DisordersBrain DiseasesCentral Nervous System DiseasesMigraine DisordersNervous System DiseasesNeurologic ManifestationsSigns and SymptomsSleep Wake DisordersPathological Conditions, Signs and SymptomsMood DisordersHeadache DisordersHeadache Disorders, Primary

Criteria

9 inclusion criteria required to participate
probands must agree to contact at least two relatives (contacting relatives is not required in cases where the participant is enrolled in just the mobile technologies assessments (EMA and Actigraphy).

Lifetime history of DSM-IV Bipolar I or Manic Episode

Lifetime history of DSM-IV Bipolar II with duration of hypomania reduced to 2 or more days (according to RDC)

Lifetime history of at least 2 episodes of DSM-IV Major Depression

Show More Criteria

1 exclusion criteria prevent from participating
The only exclusion criteria include impaired ability to comprehend the interview or inability to read.

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Study Objectives

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

National Institutes of Health Clinical Center

Bethesda, United StatesOpen National Institutes of Health Clinical Center in Google Maps
CompletedOne Study Center