Completed

Mood and Anxiety Disorders in Families Study

0 criteria met from your profileSee at a glance how your profile meets each eligibility criteria.
Study AimThis study observes the mood and anxiety disorders in families to gather diagnostic interviews, family history, and clinical evaluations to understand symptoms and impairment.
What is being collected

Data Collection

Collected from past medical records and data - Retrospective
Who is being recruted

Mental Disorders
+9

+ Brain Diseases
+ Central Nervous System Diseases
From 7 to 120 Years
+10 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Family-Based

Studying health outcomes within families in order to identify genetic or familial contributions to disease.
Observational
Study Start: May 2004
See protocol details

Summary

Principal SponsorNational Institute of Mental Health (NIMH)
Last updated: December 27, 2025
Sourced from a government-validated database.Claim as a partner
Study start date: May 21, 2004Actual date on which the first participant was enrolled.

This study aims to explore the link between mood disorders, such as bipolar disorder and major depression, and their genetic and familial patterns. Researchers are particularly interested in how these mood disorders might overlap with anxiety disorders and migraines. The study involves a wide range of participants, including individuals diagnosed with various mood and anxiety disorders, as well as their relatives. Understanding these connections could lead to better diagnosis and treatment options for people affected by these conditions, potentially improving their quality of life by tailoring interventions to more specific subgroups within the mood disorder spectrum. Participants in this study will undergo structured interviews to gather detailed information about their mental health and family history. Researchers will also collect DNA samples to look for genetic links. A subset of participants will keep electronic diaries to track their daily experiences and will measure their light exposure and activity levels. This data will help identify biological markers linked to mood disorders. The study will measure how often these disorders appear within families and will look for symptoms that might be passed down or shared. This ongoing research could reveal important insights into how mood disorders are inherited and how they interact with other health issues.

Official TitleFamily Study of Affective and Anxiety Spectrum Disorders 
NCT00071786
Principal SponsorNational Institute of Mental Health (NIMH)
Last updated: December 27, 2025
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details
1944 patients to be enrolledTotal number of participants that the clinical trial aims to recruit.
Family-Based
These studies involve members of the same family to explore how genetics and shared environments may contribute to a disease. They help researchers pinpoint inherited risk factors.

How participants are selected
Participants are selected without using randomization. They may be chosen based on convenience, access, or willingness to participate. This approach is common when random selection isn’t practical.
Another way to select participants is through a probability sample, where participants are chosen randomly, so everyone has an equal chance to be included.

How information is collected
Researchers use data that has already been collected in the past, often through medical records or historical databases. This helps identify potential patterns or risk factors after outcomes have already occurred.

Other Ways to Collect Data
Prospective: These studies collect new data moving forward over time.
Cross-sectional: These studies collect data at one single point in time.
Others: Some studies use a mix of approaches or less common designs depending on the research goal.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria
Any sexBiological sex of participants that are eligible to enroll.
From 7 to 120 YearsRange of ages for which participants are eligible to join.
Healthy volunteers not allowedIf individuals who are healthy and do not have the condition being studied can participate.
Conditions
Pathology
Mental Disorders
Brain Diseases
Central Nervous System Diseases
Migraine Disorders
Nervous System Diseases
Neurologic Manifestations
Signs and Symptoms
Sleep Wake Disorders
Pathological Conditions, Signs and Symptoms
Mood Disorders
Headache Disorders
Headache Disorders, Primary
Criteria
9 inclusion criteria required to participate
probands must agree to contact at least two relatives (contacting relatives is not required in cases where the participant is enrolled in just the mobile technologies assessments (EMA and Actigraphy).
Lifetime history of DSM-IV Bipolar I or Manic Episode
Lifetime history of DSM-IV Bipolar II with duration of hypomania reduced to 2 or more days (according to RDC)
Lifetime history of at least 2 episodes of DSM-IV Major Depression

Show More Criteria

1 exclusion criteria prevent from participating
The only exclusion criteria include impaired ability to comprehend the interview or inability to read.

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Study Objectives
Study Objectives
Primary Objectives

Diagnoses, Symptoms, Impairment, Biologic parameters

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.
This study has 1 location
Suspended
National Institutes of Health Clinical CenterBethesda, United StatesSee the location
CompletedOne Study Center