Prevention of Post-Stroke Depression - Treatment Strategy
Problem Solving Therapy
+ Escitalopram
+ Placebo
Mental Disorders+9
+ Behavioral Symptoms
+ Brain Diseases
Prevention Study
Summary
Study start date: September 1, 2002
Actual date on which the first participant was enrolled.The development of depression after a stroke is a serious condition that can have negative effects on thought, emotions, and overall daily functioning, particularly in the first year following the stroke. Evidence suggests that antidepressants may be used to prevent post-stroke depression. This study will treat nondepressed stroke patients with antidepressants or problem solving therapy (PST) to determine the most effective treatments for preventing depression. Participants in this study will be randomly assigned to receive PST, escitalopram, or placebo (an inactive pill) for 12 months. Participants who display depressive symptoms for 2 weeks or more will be removed from the study. After 12 months, treatment will be discontinued and participants will be monitored for an additional 6 months.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.201 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Prevention Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.From 31 to 89 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Inclusion Criteria: * Stroke within the last 120 days Exclusion Criteria: * DSM (Diagnostic and Statistical Manual) IV criteria for major or minor depressive disorder * Heart, respiratory, kidney, or liver failure; severely disabling musculoskeletal disorder; or cancer * Diagnosis of neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease, Multiple System Atrophy, or Huntington's disease * Pre-existing dementia or aphasia with severe language comprehension deficits * Alcohol or substance abuse or dependence within the last 12 months * Recurrent unipolar or bipolar disorder prior to the stroke
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.3 intervention groups are designated in this study
33.333% chance of being blinded to the placebo group
Treatment Groups
Group I
ExperimentalGroup II
ExperimentalGroup III
PlaceboStudy Objectives
Primary Objectives
Secondary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 3 locations
University of Iowa Hospitals and Clinics
Iowa City, United StatesBurke Rehabilitation Hospital
White Plains, United States