Assessment of Hippocampal Volume and Memory Function in Cushing's Syndrome
This study aims to observe and understand the relationship between hippocampal volume and memory function in individuals diagnosed with Cushing's Syndrome.
Data Collection
Adrenal Gland Diseases+5
+ Adrenocortical Hyperfunction
+ Pathologic Processes
Summary
Study start date: August 1, 1994
Actual date on which the first participant was enrolled.PROTOCOL OUTLINE: Patients undergo a psychiatric evaluation for mood and cognition during confirmation of diagnosis. Neuropsychologic exams include pencil and paper test and a cognitive assessment. Endocrine studies include dexamethasone and corticotropin-releasing hormone stimulation tests. The hippocampal complex volume is assessed with coronal magnetic resonance imaging. There is a follow-up 1 year after the initiation of treatment.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.12 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.From 15 to 80 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
PROTOCOL ENTRY CRITERIA: Adults and teenagers with untreated, spontaneous active Cushing's syndrome Diagnosis verified at the University of Michigan Medical Center, including the following: Excessive cortisol secretion measured by urinary-free cortisol, cortisol secretion rate, and plasma cortisol level Lack of normal circadian cortisol secretion and failure to suppress following 2 mg of dexamethasone
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location
University of Michigan Health Systems
Ann Arbor, United StatesOpen University of Michigan Health Systems in Google Maps